Is onset of lactation delayed in women with diabetes in pregnancy? A systematic review

Diabet Med. 2016 Jan;33(1):17-24. doi: 10.1111/dme.12846. Epub 2015 Aug 18.

Abstract

Aim: To determine if women with diabetes in pregnancy have a delayed onset of lactation through a systematic review of the literature.

Methods: We searched databases including MEDLINE, Web of Science, PubMed, CINAHL Plus and PsychINFO for articles assessing diabetes in pregnancy and lactogenesis. Thirty-one articles were screened and 10 articles were included in the systematic review. We extracted data on diabetes in pregnancy and onset of lactation (secretory activation or lactogenesis II).

Results: The 10 studies examining the association between women with diabetes in pregnancy and delayed onset of lactation reported a significant delay in women with diabetes compared with women without diabetes. Two studies assessed the impact of metabolic control on lactogenesis, and found an association between poorer metabolic control and delayed onset of lactation.

Conclusions: Although this review has found evidence of an association between women experiencing diabetes during pregnancy and delayed onset of lactation, the presence of many potential confounding factors need to be acknowledged.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adult
  • Confounding Factors, Epidemiologic
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / physiopathology*
  • Diabetes, Gestational / therapy
  • Female
  • Humans
  • Hyperglycemia / prevention & control
  • Hypoglycemia / prevention & control
  • Lactation
  • Lactation Disorders / epidemiology
  • Lactation Disorders / etiology*
  • Pregnancy
  • Pregnancy in Diabetics / blood
  • Pregnancy in Diabetics / physiopathology*
  • Pregnancy in Diabetics / therapy
  • Risk Factors