Application in Europe of a urine-based rapid diagnostic test for confirmation of Schistosoma mansoni infection in migrants from endemic areas

Euro Surveill. 2015 Jun 11;20(23):21151. doi: 10.2807/1560-7917.es2015.20.23.21151.

Abstract

In February 2015, a male patient from Eritrea with persistent abdominal pain and rectal bleeding was diagnosed with Schistosoma mansoni infection upon examination of a rectal biopsy. In May 2015, repeated stool microscopy identified S. mansoni infection in another Eritrean patient with abdominal pain and considerable eosinophilia (34%). Use of point-of-care circulating cathodic antigen (POC-CCA) tests on urine confirmed S. mansoni infection in both patients. Wider application of non-invasive POC-CCA urine tests will improve schistosomiasis diagnosis and clinical management in migrants.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Animals
  • Anthelmintics / therapeutic use
  • Antigens, Helminth / urine*
  • Biopsy
  • Clinical Laboratory Techniques
  • Eritrea
  • Feces / parasitology
  • Germany
  • Glycoproteins
  • Helminth Proteins
  • Humans
  • Male
  • Point-of-Care Systems*
  • Praziquantel / therapeutic use
  • Rectal Diseases
  • Schistosoma mansoni / immunology*
  • Schistosoma mansoni / isolation & purification
  • Schistosomiasis mansoni / diagnosis*
  • Schistosomiasis mansoni / drug therapy
  • Schistosomiasis mansoni / urine*
  • Sensitivity and Specificity
  • Transients and Migrants
  • Travel*
  • Treatment Outcome
  • Young Adult

Substances

  • Anthelmintics
  • Antigens, Helminth
  • CCA protein, Schistosoma mansoni
  • Glycoproteins
  • Helminth Proteins
  • Praziquantel