No effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials

Dorota Gieruszczak-Białek; Zofia Konarska; Agata Skórka; Yvan Vandenplas; Hania Szajewska

doi:10.1016/j.jpeds.2014.11.030

No effect of proton pump inhibitors on crying and irritability in infants: systematic review of randomized controlled trials

J Pediatr. 2015 Mar;166(3):767-70.e3. doi: 10.1016/j.jpeds.2014.11.030. Epub 2014 Dec 30.

Authors

Dorota Gieruszczak-Białek¹, Zofia Konarska¹, Agata Skórka¹, Yvan Vandenplas², Hania Szajewska³

Affiliations

¹ Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
² Department of Pediatrics, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
³ Department of Pediatrics, The Medical University of Warsaw, Warsaw, Poland. Electronic address: hania@ipgate.pl.

PMID: 25556017
DOI: 10.1016/j.jpeds.2014.11.030

Abstract

Proton pump inhibitors are increasingly being used to treat infants with crying and/or irritability based on the assumption that these symptoms are attributable to gastroesophageal reflux. However, the data from a systematic review of randomized controlled trials do not support the use of proton pump inhibitors to decrease infant crying and irritability.

Publication types

Review
Systematic Review

MeSH terms

Crying / psychology*
Emotions / physiology*
Gastroesophageal Reflux / drug therapy*
Gastroesophageal Reflux / psychology
Humans
Infant
Irritable Mood / drug effects*
Proton Pump Inhibitors / therapeutic use*
Randomized Controlled Trials as Topic*

Substances

Proton Pump Inhibitors