Nonoperative management of full-thickness intravenous extravasation injuries in premature neonates using enzymatic debridement

P A Falcone; D T Barrall; D R Jeyarajah; J A Grossman

doi:10.1097/00000637-198902000-00010

Nonoperative management of full-thickness intravenous extravasation injuries in premature neonates using enzymatic debridement

Ann Plast Surg. 1989 Feb;22(2):146-9. doi: 10.1097/00000637-198902000-00010.

Authors

P A Falcone¹, D T Barrall, D R Jeyarajah, J A Grossman

Affiliation

¹ Department of Plastic Surgery, Brown University Affiliated Hospitals and Veterans Administration Medical Center, Providence, RI.

PMID: 2525364
DOI: 10.1097/00000637-198902000-00010

Abstract

Peripheral intravenous fluid extravasation is a common occurrence among neonatal intensive care unit patients. Fifteen high-risk neonates, averaging less than 35 weeks' gestation and less than 1,500 g birth weight, with full-thickness extravasation injuries were successfully treated nonoperatively by a topical fibrinolysin/deoxyribonuclease ointment. All wounds healed without delaying hospital discharge, and no significant scar contractures were observed in patients followed up to 16 months after injury.

MeSH terms

Administration, Topical
Debridement
Deoxyribonucleases / therapeutic use*
Drug Combinations / therapeutic use
Extravasation of Diagnostic and Therapeutic Materials / drug therapy
Extravasation of Diagnostic and Therapeutic Materials / therapy*
Female
Fibrinolysin / therapeutic use*
Humans
Infant, Newborn
Infant, Premature, Diseases / drug therapy
Infant, Premature, Diseases / therapy*
Male
Ointments

Substances

Drug Combinations
Ointments
deoxyribonuclease, plasmin drug combination
Deoxyribonucleases
Fibrinolysin