This meta-analysis examined the relationship between emotion regulation strategies (cognitive reappraisal, expressive suppression) and mental health (measured by life-satisfaction, positive affect, depression, anxiety, and negative affect). 48 studies, which included 51 independent samples, 157 effect sizes, and 21,150 participants, met the inclusion criteria. The results showed that cognitive reappraisal was correlated significantly and positively with positive indicators of mental health (r = .26) and negatively with negative indicators of mental health (r = -.20). Expressive suppression was correlated negatively with positive indicators of mental health (r = -.12), and positively with negative indicators of mental health (r =.15). Expressive suppression was correlated positively with positive indicators of mental health within the category of samples with Western cultural values (r = -.11) but not the category with Eastern cultural values. Moreover, the correlation of expressive suppression and negative indicators of mental health was stronger in the Western cultural values category (r = .19) than in the Eastern cultural values category (r = .06). Therefore, it is necessary for follow-up studies about emotion regulation and mental health to consider some moderator variable like the culture.