The European Workshop on Immune-Mediated Inflammatory Diseases aims to exchange scientific knowledge and promote the collaboration between various disciplines (rheumatology, dermatology and gastroenterology) among physicians and scientists. This year ophthalmologists and neurologists were also present for the first time. The meeting revolved around the following topics: fibrosis, gene therapy in ophthalmology, functional genomics, challenges in human immunology, environmental factors, diabetes and metabolism, novelties in multiple sclerosis and innate lymphoid cells. The workshop was preceded by a masterclass that covered the last 15 years of IL-17/Th17 research and provided an overview on future therapeutics to battle immune-mediated inflammatory diseases.