Risk score for the prediction of contrast-induced nephropathy in elderly patients undergoing percutaneous coronary intervention

Angiology. 2013 Apr;64(3):188-94. doi: 10.1177/0003319712467224. Epub 2012 Nov 29.

Abstract

We developed a risk score for contrast-induced nephropathy (CIN) in elderly patients (n = 668) before percutaneous coronary intervention (PCI). Another 277 elderly patients were studied for validation. Based on the odds ratio, risk factors were assigned a weighted integer; the sum of the integers was the risk score. Among the 668 elderly patients, 105 (15.7%) experienced CIN. There were 9 risk factors for CIN (with weighted integer): estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) (4), diabetes (3), left ventricular ejection fraction <45% (3), hypotension (2), age >70 years (2), myocardial infarction (2), emergency PCI (2), anemia (2), and contrast agent volume >200 mL (2). The incidence of CIN was 3.4%, 11.9%, 36.9%, and 69.8% in the low-risk (≤4), moderate risk (5-8), high-risk (9-12), and very-high-risk groups (≥13). The model demonstrated good discriminative power in the validation population (c statistic = 0.79). This score can be used to plan preventative measures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary*
  • Contrast Media / adverse effects*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / epidemiology*
  • Male
  • Myocardial Infarction / epidemiology
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Stroke Volume

Substances

  • Contrast Media