Abstract
This study was designed to determine the possible protective effect of polysaccharides extract of rhizoma atractylodis macrocephalae on heart function in aged rats. Polysaccharides extract of rhizoma atractylodis macrocephalae was administered to aged rats. Results showed that thymus, spleen and cardiac indexs were significantly increased, whereas caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein expression, Smac/DIABLO and HtrA2/Omi mRNA expression levels were markedly reduced. It can be concluded that polysaccharides extract of rhizoma atractylodis macrocephalae may enhance immunity and improve heart function in aged rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis Regulatory Proteins
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Atractylodes / chemistry*
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Cardiotonic Agents / isolation & purification
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Cardiotonic Agents / pharmacology*
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Caspase 3 / metabolism
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Female
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Gene Expression / drug effects*
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Heart / drug effects*
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Hemodynamics / drug effects
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Immunologic Factors / isolation & purification
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Immunologic Factors / pharmacology
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Male
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Mitochondrial Proteins / genetics
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Mitochondrial Proteins / metabolism
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Polysaccharides / isolation & purification
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Polysaccharides / pharmacology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism
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Rats
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Rats, Sprague-Dawley
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Rhizome / chemistry*
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Serine-Arginine Splicing Factors
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Spleen / drug effects
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Thymus Gland / drug effects
Substances
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Apoptosis Regulatory Proteins
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Cardiotonic Agents
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Carrier Proteins
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DIABLO protein, rat
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Immunologic Factors
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Mitochondrial Proteins
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Nerve Tissue Proteins
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Plant Extracts
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Polysaccharides
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RNA, Messenger
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RNA-Binding Proteins
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Tra2b protein, rat
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Serine-Arginine Splicing Factors
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Casp3 protein, rat
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Caspase 3