Modern surgical therapy: limb salvage and the role of amputation for extremity soft-tissue sarcomas

Marco L Ferrone; Chandrajit P Raut

doi:10.1016/j.soc.2011.11.001

Modern surgical therapy: limb salvage and the role of amputation for extremity soft-tissue sarcomas

Surg Oncol Clin N Am. 2012 Apr;21(2):201-13. doi: 10.1016/j.soc.2011.11.001. Epub 2011 Dec 16.

Authors

Marco L Ferrone¹, Chandrajit P Raut

Affiliation

¹ Department of Orthopedics, Brigham and Women's Hospital, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

PMID: 22365515
DOI: 10.1016/j.soc.2011.11.001

Abstract

Historically the surgical management of extremity soft-tissue sarcomas (ESTS) commonly involved amputation. Nowadays limb-sparing, function-preserving surgery is the standard of care for ESTS. Adjuvant therapies such as radiation therapy and chemotherapy are used selectively in an effort to minimize both local recurrence and distant spread. Less common modalities, such as isolated limb perfusion, isolated limb infusion, and hyperthermia are being evaluated to potentially expand the cohort of individuals who may be eligible for limb-sparing surgery and to improve outcomes. This article reviews the standard and evolving approaches to the management of ESTS.

Publication types

Review

MeSH terms

Amputation, Surgical / methods*
Brachytherapy / methods
Chemotherapy, Cancer, Regional Perfusion / methods
Combined Modality Therapy
Humans
Hyperthermia, Induced / methods
Limb Salvage / methods*
Magnetic Resonance Imaging
Neoplasm Recurrence, Local / prevention & control
Randomized Controlled Trials as Topic
Risk Factors
Salvage Therapy / methods*
Sarcoma / drug therapy
Sarcoma / radiotherapy
Sarcoma / surgery*
Soft Tissue Neoplasms / drug therapy
Soft Tissue Neoplasms / radiotherapy
Soft Tissue Neoplasms / surgery*
Treatment Outcome