Asymptotic properties of mean survival estimate based on the Kaplan-Meier curve with an extrapolated tail

Pharm Stat. 2012 Mar-Apr;11(2):135-40. doi: 10.1002/pst.514. Epub 2012 Feb 10.

Abstract

Asymptotic distribution of the mean survival time based on the Kaplan-Meier curve with an extrapolated 'tail' is derived. A closed formula of the variance estimate is provided. Asymptotic properties of the estimator were studied in a simulation study, which showed that this estimator was unbiased with proper coverage probability and followed a normal distribution. An example is used to demonstrate the application of this estimator.

MeSH terms

  • Bias
  • Clinical Trials as Topic / methods*
  • Computer Simulation
  • Data Interpretation, Statistical
  • Humans
  • Kaplan-Meier Estimate*
  • Quality-Adjusted Life Years
  • Survival Analysis