Abstract
We report treatment outcomes from a retrospective cohort of patients with isoniazid-monoresistant tuberculosis in rural South Africa. Sixteen percent of patients had poor outcomes, 61% of whom progressed to multidrug-resistant tuberculosis. These data reveal the need for early identification and aggressive follow-up of isoniazid monoresistance to increase treatment success.
Publication types
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Multicenter Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antitubercular Agents / therapeutic use*
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Bacterial Proteins / genetics
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Catalase / genetics
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Cohort Studies
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Disease Progression
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Female
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Humans
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Isoniazid / therapeutic use*
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Male
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Middle Aged
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / genetics
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Retrospective Studies
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Treatment Outcome
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Tuberculosis / drug therapy*
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Tuberculosis / microbiology
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Tuberculosis, Multidrug-Resistant
Substances
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Antitubercular Agents
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Bacterial Proteins
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Catalase
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katG protein, Mycobacterium tuberculosis
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Isoniazid