Abstract
Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Aged
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Aged, 80 and over
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Aging / immunology*
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Antibody Formation / drug effects
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Antibody Formation / immunology
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Antigens, CD / immunology
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B-Lymphocyte Subsets / drug effects
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B-Lymphocyte Subsets / immunology*
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B-Lymphocytes / drug effects
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B-Lymphocytes / immunology*
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Humans
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Immunity, Cellular* / drug effects
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Immunity, Innate*
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Immunoglobulin Class Switching / drug effects
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Immunoglobulins / classification
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Immunoglobulins / immunology*
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Influenza A virus / growth & development
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Influenza Vaccines / administration & dosage
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Influenza Vaccines / immunology
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Influenza, Human / immunology
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Influenza, Human / prevention & control*
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Influenza, Human / virology
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T-Lymphocytes / immunology
Substances
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Antigens, CD
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Immunoglobulins
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Influenza Vaccines