Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data

Lancet Infect Dis. 2011 Mar;11(3):190-207. doi: 10.1016/S1473-3099(10)70295-4. Epub 2011 Jan 26.

Abstract

Background: Insecticide-treated nets and intermittent preventive treatment with sulfadoxine-pyrimethamine are recommended for the control of malaria during pregnancy in endemic areas in Africa, but there has been no analysis of coverage data at a subnational level. We aimed to synthesise data from national surveys about these interventions, accounting for disparities in malaria risk within national borders.

Methods: We extracted data for specific strategies for malaria control in pregnant women from national malaria policies from endemic countries in Africa. We identified the most recent national household cluster-sample surveys recording intermittent preventive treatment with sulfadoxine-pyrimethamine and use of insecticide-treated nets. We reconciled data to subnational administrative units to construct a model to estimate the number of pregnant women covered by a recommended intervention in 2007.

Findings: 45 (96%) of 47 countries surveyed had a policy for distribution of insecticide-treated nets for pregnant women; estimated coverage in 2007 was 4·7 million (17%) of 27·7 million pregnancies at risk of malaria in 32 countries with data. 39 (83%) of 47 countries surveyed had an intermittent preventive treatment policy; in 2007, an estimated 6·4 million (25%) of 25·6 million pregnant women received at least one dose of treatment and 19·8 million (77%) visited an antenatal clinic (31 countries). Estimated coverage was lowest in areas of high-intensity transmission of malaria.

Interpretation: Despite success in a few countries, coverage of insecticide-treated nets and intermittent preventive treatment in pregnant African women is inadequate; increased efforts towards scale-up are needed.

Funding: The Malaria in Pregnancy Consortium and Wellcome Trust.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Africa South of the Sahara / epidemiology
  • Antimalarials / administration & dosage
  • Antimalarials / therapeutic use
  • Drug Combinations
  • Female
  • Humans
  • Insecticide-Treated Bednets*
  • Malaria / epidemiology
  • Malaria / prevention & control*
  • Middle Aged
  • Mosquito Control / methods*
  • Pregnancy
  • Pregnancy Complications, Parasitic / prevention & control*
  • Pyrimethamine / administration & dosage
  • Pyrimethamine / therapeutic use
  • Sulfadoxine / administration & dosage
  • Sulfadoxine / therapeutic use
  • Young Adult

Substances

  • Antimalarials
  • Drug Combinations
  • fanasil, pyrimethamine drug combination
  • Sulfadoxine
  • Pyrimethamine