Over 8,00,000 new cases are diagnosed and 5,50,000 deaths occur annually due to cancer in India. The dramatic increase in morbidity and mortality due to cancer is a matter of concern for the society. Though the burden of cancer involves the entire nation, but the rural and underprivileged population represents majority of patients. Despite an already overwhelming burden of health problems, it is high time we must address the cancer pandemic and its alarming share of morbidity and mortality. Many large scale and innovative initiatives have been launched to counter the deadly disease. This includes efforts to expand the resources for health education and increase awareness of cancer prevention to the people and health care providers. These initiatives call for an unprecedented level of cooperation among international agencies, government and nongovernmental organizations, international foundations, healthcare system and local institutions. This review signifies the need for special attention to cancer prevention and early diagnosis with emphasis to rural and remote places of India.