White blood cell count and cardiovascular biomarkers of atherosclerosis

Biomarkers. 2010 Aug;15(5):454-60. doi: 10.3109/1354750X.2010.486870.

Abstract

Objective: To investigate the association with white blood cells (WBC) and atherosclerotic parameters including cardio-ankle vascular index (CAVI) and carotid intima-media thickness (CIMT) in the general population.

Methods: We investigated the relationship between WBC count and metabolic syndrome components, CAVI and CIMT in 3738 Japanese study participants.

Results: WBC count weakly correlated with CAVI in men (beta = 0.61, p = 0.043), but not in women (beta = 0.35, p = 0.17). On the other hand, WBC did not correlate with CIMT in either men or women (p = 0.41 and p = 0.71, respectively).

Conclusion: WBC count was associated with lipids, blood pressure and body mass index, although the correlations with CAVI and CIMT were weak or absent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Atherosclerosis / blood*
  • Atherosclerosis / diagnosis
  • Biomarkers / blood*
  • Blood Pressure
  • Body Mass Index
  • Carotid Arteries / pathology*
  • Cholesterol, HDL / blood
  • Creatinine / blood
  • Female
  • Glycated Hemoglobin / metabolism
  • Humans
  • Leukocyte Count
  • Linear Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Sex Factors
  • Smoking
  • Triglycerides / blood
  • Tunica Media / pathology*

Substances

  • Biomarkers
  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Triglycerides
  • Creatinine