Abstract
DL-beta-N-methylamino-alanine (DL-BMAA; 1-10 mumol i.c.v.) in mice induced a syndrome of: ataxia, ptosis, scratching, jumping, myoclonic jerks, clonic muscle spasms and tonic seizure, which was unaffected by pretreatment with D(-)-4-(3-phosphonoprop-2-enyl)-piperazine-2-carboxylate (D(-)-CPPene; i.p.), or by co-administration of gamma-D-glutamylamino-methylsulphonate (gamma-D-GAMS with DL-BMAA; i.c.v.). Pretreatment with 1-(aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzodiazepine (GYKI 52466; i.v.) decreased the incidence of clonic seizures for DL-BMAA, kainic acid and RS-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (RS-AMPA; i.c.v.). These results suggest an involvement of the AMPA/quisqualate subtype of excitatory amino acid receptors in acute BMAA toxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids, Diamino / pharmacology*
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Animals
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Anti-Anxiety Agents / pharmacology
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Anticonvulsants / pharmacology
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Behavior, Animal / drug effects
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Benzodiazepines / pharmacology
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Cyanobacteria Toxins
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Glutamine / analogs & derivatives
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Glutamine / pharmacology
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Ibotenic Acid / analogs & derivatives
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Ibotenic Acid / pharmacology
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Injections, Intraventricular
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Kainic Acid / pharmacology
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Kinetics
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Male
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Mice
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N-Methylaspartate / pharmacology
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Organophosphorus Compounds / pharmacology
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Piperazines / pharmacology
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Receptors, Drug / drug effects
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Receptors, Drug / metabolism*
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Receptors, N-Methyl-D-Aspartate / drug effects
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Substances
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Amino Acids, Diamino
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Anti-Anxiety Agents
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Anticonvulsants
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Cyanobacteria Toxins
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Organophosphorus Compounds
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Piperazines
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Receptors, Drug
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Receptors, N-Methyl-D-Aspartate
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Glutamine
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GYKI 52466
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beta-N-methylamino-L-alanine
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Benzodiazepines
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SDZ EAA 494
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Ibotenic Acid
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N-Methylaspartate
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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gamma-glutamylaminomethylsulfonic acid
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Kainic Acid