Investigation of bias due to loss of participants in a Dutch multicentre prospective spinal cord injury cohort study

J Rehabil Med. 2009 Apr;41(5):382-9. doi: 10.2340/16501977-0346.

Abstract

Objective: To determine bias due to loss of participants (attrition bias) in a prospective cohort study.

Design: A multi-centre prospective cohort study.

Subjects: A total of 225 individuals with a spinal cord injury from 8 Dutch rehabilitation centres.

Methods: Participants were considered non-participants when no information was collected at the measurement one year after discharge from inpatient rehabilitation. Using bivariate tests participants and non-participants were compared regarding personal, lesion, function and functional characteristics determined at the beginning of inpatient rehabilitation and at discharge. A logistic regression was performed to determine which characteristics predict participation at one year after discharge.

Results: Of the participants at the start of the study, 31% (n = 69) did not perform the tests one year after discharge from inpatient rehabilitation. Variables associated with study participation one year after discharge were: higher level of education, higher well-being score at the start of rehabilitation, and a shorter length of stay in hospital and rehabilitation centre at discharge of inpatient rehabilitation.

Conclusion: Selective attrition in the longitudinal study might have led to an over-estimation of some of the results of the measurement one year after discharge from inpatient rehabilitation.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adolescent
  • Adult
  • Aged
  • Bias*
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Patient Dropouts* / statistics & numerical data
  • Patient Participation* / statistics & numerical data
  • Prospective Studies
  • Spinal Cord Injuries / rehabilitation*
  • Young Adult