Establishing non-inferiority in treatment trials in psychiatry: guidelines from an Expert Consensus Meeting

J Psychopharmacol. 2008 Jun;22(4):409-16. doi: 10.1177/0269881108091068.

Abstract

Comparing the efficacy of different treatments in psychiatry is difficult for many reasons, even when they are investigated in "head-to-head" studies. A consensus meeting was, therefore, held to produce best practice guidelines for such studies. This article presents the conclusions of this consensus and illustrates it using published data in the field of antidepressant treatment of generalized anxiety disorder.

Publication types

  • Comparative Study

MeSH terms

  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / therapeutic use*
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / drug therapy*
  • Consensus Development Conferences as Topic
  • Cyclohexanols / adverse effects
  • Cyclohexanols / therapeutic use*
  • Duloxetine Hydrochloride
  • Evidence-Based Medicine*
  • Humans
  • Practice Guidelines as Topic*
  • Randomized Controlled Trials as Topic
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Thiophenes / adverse effects
  • Thiophenes / therapeutic use*
  • Venlafaxine Hydrochloride

Substances

  • Antidepressive Agents
  • Cyclohexanols
  • Serotonin Uptake Inhibitors
  • Thiophenes
  • Venlafaxine Hydrochloride
  • Duloxetine Hydrochloride