Nonpharmacologic interventions are important adjuncts to treatment modalities for patients with cancer pain. A variety can be used to reduce pain and concomitant mood disturbance and increase quality of life. Physicians may feel relatively uninformed about which modalities have been used for patients with cancer and have scientific support. This article reviews several nonpharmacologic and complementary and alternative modalities commonly used by patients with cancer pain. It focuses on those having empirical support or promising preliminary evidence, with the goal of familiarizing physicians with therapies that may complement regular oncologic care. This review updates an article published in November 2005. An anecdotal case study has been added to illustrate incorporation of nonpharmacologic and complementary therapies in the treatment of a patient with cancer-related pain.