Early diagnosis of neurologic conditions is crucial for successful early intervention; therefore, minimally invasive diagnostic procedures are invaluable during the neonatal period. The clinical usefulness of one such technique, the electroencephalogram (EEG), is well documented. However, the advent of high-density recording systems has extended its application. High-density EEG recording uses a significantly increased number of recordings sites: 128 to 256 electrodes compared with 10 to 30 in standard recording systems. This report describes the benefits of using more electrode sites and highlights the use of related procedures for the assessment of neural integrity across sensory modalities.