Abstract
Vanadate can be bioequivalent to phosphate and replace it in cellular metabolism. The detection of insulin-like activity has spurred interest in the development of oral anti-diabetic drugs containing vanadium. We collected and evaluated a vast toxicity data set and discussed molecular aspects related to insulin-mimetic effects of vanadium complexes.
MeSH terms
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Amino Acid Sequence
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Animals
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Chelating Agents / chemistry
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Humans
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Hypoglycemic Agents* / chemistry
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Hypoglycemic Agents* / pharmacokinetics
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Hypoglycemic Agents* / therapeutic use
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Hypoglycemic Agents* / toxicity
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Models, Molecular
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Molecular Sequence Data
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Vanadium Compounds / chemistry
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Vanadium Compounds / pharmacokinetics
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Vanadium Compounds / pharmacology*
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Vanadium Compounds / therapeutic use
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Vanadium Compounds / toxicity
Substances
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Chelating Agents
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Hypoglycemic Agents
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Vanadium Compounds