Abstract
Using MRI and voxel-based morphometry, the authors investigated 20 patients with chronic tension type headache (CTTH) and 20 patients with medication-overuse headache and compared them to 40 controls with no headache history. Only patients with CTTH demonstrated a significant gray matter decrease in regions known to be involved in pain processing. The finding implies that the alterations are specific to CTTH rather than a response to chronic head pain or chronification per se.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Age Factors
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Age of Onset
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Atrophy / diagnosis*
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Atrophy / etiology
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Atrophy / physiopathology
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Brain / pathology*
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Brain / physiopathology
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Brain Mapping
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Female
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Functional Laterality / physiology
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Headache Disorders, Secondary / chemically induced
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Headache Disorders, Secondary / diagnosis*
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Headache Disorders, Secondary / physiopathology
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Humans
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Predictive Value of Tests
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Tension-Type Headache / diagnosis*
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Tension-Type Headache / physiopathology
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Tryptamines / adverse effects
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Tryptamines