The purpose of this study was to compare the health descriptions and perceptions of adults with multiple sclerosis living in rural and urban areas. Data were obtained from 361 adults, who responded to a mail survey including standardized self-report measures of physical and mental health, disability and social support, and an open-ended question on the meaning of health. In contrast to findings with general, nonclinical populations, the health perceptions and descriptions of this chronically ill population were not significantly affected by their place of residence. Further research is needed to examine the applicability of health-related findings from general populations to persons who are chronically ill.