Abstract
The novel immunomodulator FTY720 is remarkably effective in models of transplantation and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four sphingosine 1-phosphate receptors. Stimulation of sphingosine 1-phosphate receptors leads to sequestration of lymphocytes in secondary lymphatic tissues and thus away from inflammatory lesions and graft sites.
MeSH terms
-
Animals
-
Autoimmune Diseases / drug therapy*
-
Bone Marrow Transplantation / immunology
-
Clinical Trials as Topic
-
Fingolimod Hydrochloride
-
Humans
-
Immunosuppressive Agents / therapeutic use*
-
Islets of Langerhans Transplantation / immunology
-
Lymph Nodes / immunology
-
Peyer's Patches / immunology
-
Propylene Glycols / pharmacology
-
Propylene Glycols / therapeutic use*
-
Receptors, Cell Surface / drug effects*
-
Receptors, G-Protein-Coupled*
-
Receptors, Lysophospholipid
-
Sphingosine / analogs & derivatives
Substances
-
Immunosuppressive Agents
-
Propylene Glycols
-
Receptors, Cell Surface
-
Receptors, G-Protein-Coupled
-
Receptors, Lysophospholipid
-
Fingolimod Hydrochloride
-
Sphingosine