Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes

J Pediatr. 2001 Jul;139(1):137-40. doi: 10.1067/mpd.2001.115312.

Abstract

Two premature female infants had severe hyperbilirubinemia caused by hemolysis. Both neonates were heterozygotes for the glucose-6-phosphate dehydrogenase Mediterranean mutation as determined by DNA analysis. Glucose-6-phosphate dehydrogenase-deficient heterozygotes may be susceptible to the complications of this enzyme deficiency.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • DNA Mutational Analysis
  • Female
  • Glucosephosphate Dehydrogenase Deficiency / genetics*
  • Hemolysis*
  • Heterozygote
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / genetics*
  • Jaundice, Neonatal / genetics*