Abstract
Changes in subjective sensations due to xerostomia before and after administration of Xialine, a xanthan gum-based saliva substitute, were evaluated in 30 patients with radiation-induced xerostomia using the QLQ-H&N35. Xerostomia in general decreased with both Xialine and placebo to almost the same degree. A trend was seen for Xialine to improve problems with speech and senses.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Aged
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Chi-Square Distribution
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Cross-Over Studies
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Double-Blind Method
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Female
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Head and Neck Neoplasms / radiotherapy
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Humans
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Male
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Middle Aged
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Pilot Projects
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Polysaccharides, Bacterial / therapeutic use*
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Radiotherapy / adverse effects
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Saliva, Artificial / therapeutic use*
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Surveys and Questionnaires
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Xerostomia / drug therapy*
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Xerostomia / etiology
Substances
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Polysaccharides, Bacterial
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Saliva, Artificial
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xialine
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xanthan gum