Parkinsonian symptoms as an initial manifestation in a Japanese patient with acquired immunodeficiency syndrome and Toxoplasma infection

Intern Med. 2000 Dec;39(12):1111-4. doi: 10.2169/internalmedicine.39.1111.

Abstract

We studied a Japanese patient who developed parkinsonian symptoms over 3 months before the diagnosis of acquired immunodeficiency syndrome. Brain MRI showed multiple lesions with mass effect and ring enhancement in the basal ganglia and subcortical white matter suggesting Toxoplasma infection. Anti-Toxoplasma therapy and highly active antiretroviral therapy for 6 months allowed improvement of parkinsonism, brain MRI findings, and immune system.

Publication types

  • Case Reports
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / complications*
  • AIDS-Related Opportunistic Infections / drug therapy
  • Antiprotozoal Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • Carbidopa / therapeutic use
  • Corpus Striatum / parasitology
  • Corpus Striatum / pathology
  • Humans
  • Levodopa / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parietal Lobe / parasitology
  • Parietal Lobe / pathology
  • Parkinsonian Disorders / drug therapy
  • Parkinsonian Disorders / etiology*
  • Parkinsonian Disorders / parasitology
  • Pyrimethamine / therapeutic use
  • Syphilis / complications
  • Toxoplasmosis, Cerebral / complications*
  • Toxoplasmosis, Cerebral / drug therapy

Substances

  • Antiprotozoal Agents
  • Levodopa
  • Carbidopa
  • Pyrimethamine