Long term care facilities (LTCFs) include a variety of different types of healthcare settings, each with their own unique infectious disease problems. This report focuses on the epidemiological considerations, risk factors and types of infections that occur in elderly patients institutionalized in nursing home settings. In the US, the number of patients in nursing homes continues to grow as the population ages. Today, patients in nursing homes have more complicated medical conditions than they did five years ago as they become even more elderly and the trend continues towards shorter and shorter hospital stays in acute care facilities. The patient population in nursing homes is uniquely susceptible to infections because of the physiological changes that occur with ageing, the underlying chronic diseases of the patients and the institutional environment within which residents socialize and live. In addition, in nursing home settings, problems with infections may be more difficult to diagnose because of their subtle presentations, the presence of co-morbid illnesses which obscure the symptoms of infection and the lack of on site diagnostic facilities. Delays in diagnosing and treating infections allow transmission to occur within the facility. Both endemic and epidemic infections occur relatively commonly in nursing homes. The incidence of endemic infections, such as catheter-associated urinary tract infections, lower respiratory infections and skin infections, is influenced by the debility level of the patients. Calculations of infection rates are influenced by the intensity of surveillance methods at each institution. Many endemic infections are unpreventable. Epidemic infections account for 10-20% of nursing home infections. These include clusters of upper or lower respiratory infections, gastroenteritis, diarrhoea, and catheter-associated UTI's. Epidemic infections are potentially preventable with sound infection control practices. Special attention must be paid to promote universal precautions and give certain patients, such as those with known infection or colonization with Clostridium difficile, MRSA or VRE, special consideration. The potential for epidemic infections with antibiotic-resistant organisms is real. In the nursing home setting, attention must be given to develop and support strong infection control programmes that can monitor the occurrence of institutionally-acquired infections and initiate control strategies to prevent the spread of epidemic infections. Education in infection control issues and attention to employee health is essential to enable staff to care appropriately for today's nursing home population and to prepare them for the even more complicated patients who will be cared for in this type of setting in future.