Abstract
Transverse myelitis is a focal inflammatory disorder of the spinal cord which may arise due to different etiologies. Transverse myelitis may be idiopathic or related/secondary to other diseases including infections, connective tissue disorders and other autoimmune diseases. It may be also associated with optic neuritis (neuromyelitis optica), which may precede transverse myelitis. In this manuscript we review the pathophysiology of different types of transverse myelitis and neuromyelitis optica and discuss diagnostic criteria for idiopathic transverse myelitis and risk of development of multiple sclerosis after an episode of transverse myelitis. We also discuss treatment options including corticosteroids, immunosuppressives and monoclonal antibodies, plasma exchange and intravenous immunoglobulins.
Keywords: Transverse myelitis, neuromyelitis optica, epidemiology, pathology, pathogenesis, treatment, IDIOPATHIC TRANSVERSE MYELITIS, thoracic cord, pneumonia bacteria
Current Neuropharmacology
Title: Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles,Pathophysiology and Therapeutic Choices
Volume: 9 Issue: 3
Author(s): Amer Awad and Olaf Stuve
Affiliation:
Keywords: Transverse myelitis, neuromyelitis optica, epidemiology, pathology, pathogenesis, treatment, IDIOPATHIC TRANSVERSE MYELITIS, thoracic cord, pneumonia bacteria
Abstract: Transverse myelitis is a focal inflammatory disorder of the spinal cord which may arise due to different etiologies. Transverse myelitis may be idiopathic or related/secondary to other diseases including infections, connective tissue disorders and other autoimmune diseases. It may be also associated with optic neuritis (neuromyelitis optica), which may precede transverse myelitis. In this manuscript we review the pathophysiology of different types of transverse myelitis and neuromyelitis optica and discuss diagnostic criteria for idiopathic transverse myelitis and risk of development of multiple sclerosis after an episode of transverse myelitis. We also discuss treatment options including corticosteroids, immunosuppressives and monoclonal antibodies, plasma exchange and intravenous immunoglobulins.
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Cite this article as:
Awad Amer and Stuve Olaf, Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles,Pathophysiology and Therapeutic Choices, Current Neuropharmacology 2011; 9 (3) . https://dx.doi.org/10.2174/157015911796557948
DOI https://dx.doi.org/10.2174/157015911796557948 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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