Abstract
Psoriasis is a chronic, immune-mediated skin disorder that affects 1–3% of the general population worldwide. While considered a non-life-threatening disease, psoriasis represents a social and financial burden for patients and the healthcare system. Individuals suffer from disfigurement and from social stigmatization. Because the disease is usually persistent, patients with a diagnosis of psoriasis usually need lifelong care, which also means a lifetime of expenses. We aimed to conduct a comprehensive review of the evidence available concerning the social burden and costs of psoriasis.
A search for the keywords ‘quality of life’ (QOL) or ‘burden’ or ‘stigmatization’ or ‘psychological factors’ in PubMed up to January 2010 yielded a total of 817 studies. QOL was affected by psoriasis to a degree comparable with diabetes or cancer. A search for ‘cost-of-illness analyses’, in the same period, yielded only seven papers satisfying entry criteria. All the studies but one were performed before biologics became available for psoriasis treatment. Direct costs were higher than indirect costs, with hospitalization representing the most significant item. Treatment costs showed wide variations between different studies. Reasons for these discrepancies are manifold including differences in the selection of the sample, as well as in the methods for calculating costs. There is a need to harmonize methodologies. For a final conclusive judgement of the cost effectiveness of innovative therapies such as biological agents, long-term economic consequences have to be evaluated and long-term remission rates and complications considered.
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References
Naldi L. Epidemiology of psoriasis. Curr Drug Targets Inflamm Allergy 2004; 3: 121–8.
Naldi L, Gambini D. The clinical spectrum of psoriasis. Clinics Dermatol 2007; 25: 510–8.
Jobling R, Naldi L. Assessing the impact of psoriasis and the relevance of qualitative research. J Invest Dermatol 2006; 126: 1438–40.
Helliwell PS, Taylor WJ. Classification and diagnostic criteria for psoriatic arthritis. Ann Rheum Dis 2005; 64 Suppl. 2: ii3–8.
Nijsten T, Wakkee M. Complexities of the association between psoriasis and comorbidities. J Invest Dermatol 2009; 129: 1601–3.
Gelfand JM, Neimann AL, Shin DB, et al. Risk of myocardial infarction in patients with psoriasis. JAMA 2006; 296: 1735–41.
Naldi L, Mercuri SR. Epidemiology of comorbidities in psoriasis. Dermatol Ther 2010; 23: 114–8.
Nijsten T, Looman CW, Stern RS. Clinical severity of psoriasis in last 20 years of PUVA study. Arch Dermatol 2007; 143: 1113–21.
Naldi L, Minelli C. Dermatology. In: Machin D, Day S, Green SB, editors. Textbook of clinical trials. 2nd rev. ed. Chichester: John Wiley & Sons, 2007: 261–86.
Bronsard V, Paul C, Prey S, et al. What are the best outcome measures for assessing quality of life in plaque type psoriasis? A systematic review of the literature. J Eur Acad Dermatol Venereol 2010; 24 Suppl. 2: 17–22.
Jobling R. The experience of psoriasis under treatment. In: Anderson R, Bury M, editors. Living with chronic illness. London: Unwin Hyman, 1988: 225–44.
EMA Committee for Proprietary Medical Products. Note for guidance on clinical investigation of medical products indicated for the treatment of psoriasis [report no. CPMP/EWP 2454/02]. London: EMA, 2002.
Naldi L, Griffiths CME. Traditional therapies in the management of moderate to severe chronic plaque psoriasis: an assessment of the benefits and risks. Br J Dermatol 2005; 152: 597–615.
Poulin Y, Langley RG, Teixeira HD, et al. Biologics in the treatment of psoriasis: clinical and economic overview. J Cutan Med Surg 2009; 13 Suppl. 2: S49–57.
Horn EJ, Fox KM, Patel V, et al. Are patients with psoriasis undertreated? Results of National Psoriasis Foundation survey. J Am Acad Dermatol 2007; 57: 957–62.
Kimball AB, Jacobson C, Weiss S, et al. The psychosocial burden of psoriasis. Am J Clin Dermatol 2005; 6: 383–92.
Kimball AB, Gieler U, Linder D, et al. Psoriasis: is the impairment to a patient’s life cumulative? J Eur Acad Dermatol Venereol 2010; 24 (9): 989–1004.
Rapp SR, Feldman SR, Exum ML, et al. Psoriasis causes as much disability as other major medical diseases. J Am Acad Dermatol 1999; 41 (3 Pt 1): 401–7.
Richards HL, Fortune DG, Griffiths CE, et al. The contribution of perceptions of stigmatisation to disability in patients with psoriasis. J Psychosom Res 2001; 50: 11–5.
Davidsson S, Blomqvist K, Molin L, et al. Lifestyle of Nordic people with psoriasis. Int J Dermatol 2005; 44: 378–83.
Unaeze J, Nijsten T, Murphy A, et al. Impact of psoriasis on health-related quality of life decreases over time: an 11-year prospective study. J Invest Dermatol 2006; 126: 1480–9.
Gupta MA, Schork N. Suicidal ideation in psoriasis. Int J Dermatol 1993; 32: 188–90.
Sampogna F, Picardi A, Chren M-M, et al. Association between poorer quality of life and psychiatric morbidity in patients with different dermatological conditions. Psychosom Med 2004; 66: 620–4.
Langley RGB, Krueger GG, Griffiths CEM. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis 2005; 64 Suppl. II: ii18–23.
Schmid-Ott G, Schallmayer S, Calliess IT. Quality of life in patients with psoriasis and psoriasis arthritis with a special focus on stigmatization experience. Clin Dermatol 2007; 25: 547–54.
Schmid-Ott G, Künsebeck HW, Jäger B, et al. Significance of the stigmatization experience of psoriasis patients: a 1-year follow-up of the illness and its psychosocial consequences in men and women. Acta Derm Venereol 2005; 85 (1): 27–32.
Horn EJ, Fox KM, Patel V, et al. Association of patient-reported psoriasis severity with income and employment. J Am Acad Dermatol 2007; 57: 963–71.
Eghlileb AM, Davies EEG, Finlay AY. Psoriasis has a major secondary impact on the lives of family members and partners. Br J Dermatol 2007; 156: 1245–50.
Berger K, Ehlken B, Kugland B, et al. Cost-of-illness in patients with moderate and severe chronic psoriasis vulgaris in Germany. J Dtsch Dermatol Ges 2005; 3: 511–8.
Carrascosa JM, Pujol R, Daudén E, et al. A prospective evaluation of psoriasis in Spain (EPIDERMA project: phase II). J Eur Acad Dermatol Venereol 2006; 20: 840–5.
Schœffski O, Augustin M, Prinz J, et al. Costs and quality of life in patients with moderate to severe plaque-type psoriasis in Germany: a multi-center study. J Dtsch Dermatol Ges 2007; 5: 209–18.
Colombo G, Altomare G, Peris K, et al. Moderate and severe plaque psoriasis: cost-of-illness study in Italy. Ther Clin Risk Manag 2008; 4: 559–68.
Navarini AA, Laffitte E, Conrad C, et al. Estimation of cost-of-illness in patients with psoriasis in Switzerland. Swiss Med Wkly 2010; 140: 85–91.
Yu AP, Tang J, Xie J, et al. Economic burden of psoriasis compared to the general population and stratified by disease severity. Curr Med Res Opin, 2009; 25: 2429–38.
Beyer V, Wolverton ES. Recent trends in systemic psoriasis treatment costs. Arch Dermatol 2010; 146: 46–54.
European Network of Health Economics Evaluation Databases [online]. Available from URL: http://infodoc.inserm.fr/euronheed [Accessed 2011 Dec 15].
Lecluse LL, Naldi L, Stern RS, et al. National registries of systemic treatment for psoriasis and the European ‘Psonet’ initiative. Dermatology 2009; 218: 347–56.
Acknowledgements
Conflicts of interest: No sources of funding were used to prepare this article. The authors have no conflicts of interest that are directly relevant to the content of this article and the opinions expressed are those of the authors.
Author contributions: Dr Naldi had full access to all study data and takes responsibility for data integrity and analysis accuracy.
Study concept and design: Naldi, Garattini
Data search and acquisition: Raho, Koleva
Critical appraisal of data: Raho, Koleva, Naldi
Drafting of the manuscript: Raho, Koleva, Naldi
Critical revision of the manuscript content: Naldi, Garattini.
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Raho, G., Mihajlova Koleva, D., Garattini, L. et al. The Burden of Moderate to Severe Psoriasis. PharmacoEconomics 30, 1005–1013 (2012). https://doi.org/10.2165/11591580-000000000-00000
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DOI: https://doi.org/10.2165/11591580-000000000-00000