Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Mechanisms Behind the Anti-inflammatory Actions of Insulin
ABSTRACT
The epidemic of diabetes mellitus is worsening worldwide. Diabetes mellitus is a chronic metabolic disease characterized by inappropriate recurrent or persistent hyperglycemia. Numerous studies have demonstrated that hyperglycemia, the most significant predictor of poor clinical outcome in diabetes mellitus patients, can directly promote an inflammatory response and oxidative stress. Although there are various causes of DM, all eventually lead to absolute or relative insulin deficiency and death of pancreatic β-cells. Thus, insulin inevitably becomes the primary medication used to treat the disease and prevent diabetic complications in all DM patients. Interestingly, an emerging body of evidence suggests that insulin suppresses the inflammatory process, not only through preventing hyperglycemia but also by modulating key inflammatory molecules. In this review, we discuss the findings of studies done in vitro as well as clinical trials that have demonstrated an anti-inflammatory action of insulin and that have pointed to mechanisms responsible for this effect. Further, we discuss how the anti-inflammatory action of insulin bears on our current understanding of the pathophysiology and complications of both type 1 and type 2 diabetes.
-
King-Morris Kelli, Ikizler T. Alp, Insulin Resistance in Patients Undergoing Peritoneal Dialysis: Can We Improve It?, Cardiovascular Drugs and Therapy, 26, 6, 2012. Crossref
-
Jansen H. J., Stienstra R., van Diepen J. A., Hijmans A., van der Laak J. A., Vervoort G. M. M., Tack C. J., Start of insulin therapy in patients with type 2 diabetes mellitus promotes the influx of macrophages into subcutaneous adipose tissue, Diabetologia, 56, 12, 2013. Crossref
-
Schauss Alexander G., Açai Fruits: Potent Antioxidant and Anti-Inflammatory Superfruits with Potential Health Benefits, in Dried Fruits, 2013. Crossref
-
Harcourt Brooke E., Penfold Sally A., Forbes Josephine M., Coming full circle in diabetes mellitus: from complications to initiation, Nature Reviews Endocrinology, 9, 2, 2013. Crossref
-
Bergmann Katarzyna, Sypniewska Grazyna, Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) — Potential new biomarkers for β-cell dysfunction and diabetes, Clinical Biochemistry, 47, 7-8, 2014. Crossref
-
Stoecklein Katrin, Eekhof Elisabeth W.M., Loer Stephan A., Boer Christa, Does insulin and not reduced blood glucose levels decrease postoperative infections?, European Journal of Anaesthesiology, 29, 8, 2012. Crossref
-
Saager Leif, Duncan Andra E., Yared Jean-Pierre, Hesler Brian D., You Jing, Deogaonkar Anupa, Sessler Daniel I., Kurz Andrea, Intraoperative Tight Glucose Control Using Hyperinsulinemic Normoglycemia Increases Delirium after Cardiac Surgery, Anesthesiology, 122, 6, 2015. Crossref
-
Cao Liou, Mou Shan, Fang Wei, Gu Leyi, Huang Jiaying, Gu Aiping, Qian Jiaqi, Ni Zhaohui, Hyperleptinaemia, insulin resistance and survival in peritoneal dialysis patients, Nephrology, 20, 9, 2015. Crossref
-
Scheen A.J., Esser N., Paquot N., Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control, Diabetes & Metabolism, 41, 3, 2015. Crossref
-
Ślusarz Anna, Pulakat Lakshmi, The two faces of miR-29, Journal of Cardiovascular Medicine, 16, 7, 2015. Crossref
-
Straub Rainer H., Energy and Volume Regulation, in The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae, 2015. Crossref
-
References, in The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae, 2015. Crossref
-
Straub Rainer H., Pathogenesis and Neuroendocrine Immunology, in The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae, 2015. Crossref
-
Zhao Gang, Dharmadhikari Gitanjali, Maedler Kathrin, Meyer-Hermann Michael, Meier-Schellersheim Martin, Possible Role of Interleukin-1β in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies, PLoS Computational Biology, 10, 8, 2014. Crossref
-
Capuron Lucile, Lasselin Julie, Castanon Nathalie, Role of Adiposity-Driven Inflammation in Depressive Morbidity, Neuropsychopharmacology, 42, 1, 2017. Crossref
-
Bullon Pedro, Marin-Aguilar Fabiola, Roman-Malo Lourdes, AMPK/Mitochondria in Metabolic Diseases, in AMP-activated Protein Kinase, 107, 2016. Crossref
-
Esser N., Paquot N., Scheen A. J., Inflammatory markers and cardiometabolic diseases, Acta Clinica Belgica, 70, 3, 2015. Crossref
-
Ma Shao-gang, Jin Yao, Hu Wen, Bai Feng, Xu Wen, Yu Wei-nan, Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics with and without Ketosis, Biomarker Insights, 7, 2012. Crossref
-
Xiang Lusha, Lu Silu, Mittwede Peter N., Clemmer John S., Husband Graham W., Hester Robert L., β2-Adrenoreceptor blockade improves early posttrauma hyperglycemia and pulmonary injury in obese rats, American Journal of Physiology-Heart and Circulatory Physiology, 307, 4, 2014. Crossref
-
Valentino Rossella, D’Esposito Vittoria, Passaretti Federica, Liotti Antonietta, Cabaro Serena, Longo Michele, Perruolo Giuseppe, Oriente Francesco, Beguinot Francesco, Formisano Pietro, Nadal Angel, Bisphenol-A Impairs Insulin Action and Up-Regulates Inflammatory Pathways in Human Subcutaneous Adipocytes and 3T3-L1 Cells, PLoS ONE, 8, 12, 2013. Crossref
-
Triggle Chris R., Ding Hong, Cardiovascular impact of drugs used in the treatment of diabetes, Therapeutic Advances in Chronic Disease, 5, 6, 2014. Crossref
-
Liu Lu, Du Xiaohuang, Zhang Zuo, Zhou Jiyin, Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice, European Journal of Pharmacology, 836, 2018. Crossref
-
Gandhi Vivek D., Shrestha Palikhe Nami, Hamza Shereen M., Dyck Jason R.B., Buteau Jean, Vliagoftis Harissios, Insulin decreases expression of the proinflammatory receptor proteinase-activated receptor-2 on human airway epithelial cells, Journal of Allergy and Clinical Immunology, 142, 3, 2018. Crossref
-
Rastogi Deepa, Dixon Anne E., Mechanistic insights from human studies of asthma, in Mechanisms and Manifestations of Obesity in Lung Disease, 2019. Crossref
-
Kuwabara Wilson Mitsuo Tatagiba, Yokota Caroline Naomi Fukusawa, Curi Rui, Alba-Loureiro Tatiana Carolina, Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils, Scientific Reports, 8, 1, 2018. Crossref
-
Vijayakanthi Nandini, Greally John M., Rastogi Deepa, Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation, Pediatrics, 137, 5, 2016. Crossref
-
Pezhman Laleh, Tahrani Abd, Chimen Myriam, Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref
-
Xiong Xiaoxing, White Robin E., Xu Lijun, Yang Liya, Sun Xiaoyun, Zou Bende, Pascual Conrado, Sakurai Takeshi, Giffard Rona G., Xie Xinmin (Simon), Mitigation of Murine Focal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation, Stroke, 44, 3, 2013. Crossref
-
Wang Xinying, Niu Chenglin, Lu Jun, Li Ning, Li Jieshou, Hydrolyzed protein supplementation improves protein content and peroxidation of skeletal muscle by adjusting the plasma amino acid spectrums in rats after exhaustive swimming exercise: a pilot study, Journal of the International Society of Sports Nutrition, 11, 1, 2014. Crossref
-
Shirvani Fahimeh, Sedighi Mohsen, Shahzamani Mehran, Metabolic disturbance affects postoperative cognitive function in patients undergoing cardiopulmonary bypass, Neurological Sciences, 43, 1, 2022. Crossref