Chest
Original Research: COPDDiffusing Capacity for Carbon Monoxide Correlates Best With Tissue Volume From Quantitative CT Scanning Analysis
Section snippets
Patient Selection
The patients reported in this analysis all presented with smoking-related, upper-lobe-predominant emphysema. They were evaluated and considered eligible for participation in one of five studies of bronchoscopic lung-volume reduction by implantation of intrabronchial valves (Spiration, Inc). The studies were carried out in North America, Europe, and South Africa (e-Tables 1, Table 2). Typical inclusion and exclusion criteria for these studies have been previously published23, 26, 27, 28, 29 and
Baseline Patient Characteristics
The characteristics of patients (N = 460) are shown in Table 2. Their mean ± SD age was 64.2 ± 6.8 years, and mean BMI was 25.8 ± 5.0. Just over one-half of the cohort (57.2%) were men, and 42.8% of the patients were women. Pulmonary function testing was performed at the beginning of the study. Spirometry showed an average FEV1/FVC of 32.8%. FEV1 was 30.6% ± 8.0% predicted and FVC was 71.8% ± 16.0% predicted. Patients had significant hyperinflation, with average TLC of 129.5% ± 18.1% predicted
Acknowledgments
Author contributions: C. B. C. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. I. B. served as principal author. S. S., X. G., H. O. C., and C. B. C. contributed to the study concept and design; data acquisition, analysis, and interpretation; and manuscript revision; I. B. contributed to data analysis and revision and writing the manuscript; and W. S. contributed to data analysis and manuscript
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FUNDING/SUPPORT: This study was supported by Spiration Inc.
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