Chest
Original ResearchSleep in Critically Ill Chemically Paralyzed Patients Requiring Mechanical Ventilation
Section snippets
Study Site
The study was performed between June 1, 1999, and December 31, 2000, in the adult medical ICU at the University of California, Davis. The study protocol and consent form were approved by the Institutional Review Board of the Human Subjects Committee. Written informed consent was obtained from the patient or family member if the patient had any altered sensorium or was unable to read or write. All patients were in private rooms that were enclosed on three sides and separated from the nursing
Patient Demographics
A total of 20 patients were enrolled in the study. Eighteen patients underwent final analysis. One patient withdrew from the study after consent was obtained. The recorder malfunctioned during data acquisition in another patient. The study population characteristics are given in Table 1. Overall, ages ranged from 27 to 74 years with a younger population in the CS group (p < 0.02). When the one outlier, a 27-year-old patient, was eliminated from age analysis, no statistical difference existed
Discussion
This is the first study to our knowledge to prospectively compare various groups of critically ill patients requiring mechanical ventilation based on medication regimen. This is one of the largest studies investigating sleep in severely ill patients in the ICU and adds new information in a novel group of patients: those receiving chemical paralysis. As noted in previous studies6, 7 in patients requiring mechanical ventilation, all of our patients displayed abnormal sleep/wake cycles with
ACKNOWLEDGMENT
We thank LeNette Mahan, BSN, and give a special recognition for her participation in establishing the protocol and preparation of each patient for the study and instruction of nursing staff. We extend our thanks to all nursing staff in the medical ICU who participated and cared for the patients, and acknowledge Grant O’Conner, BSN, for his diligence.
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Supported by a grant from the American Lung Association.