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Clinical InvestigationsCOPDRelationship Between Serum 25-Hydroxyvitamin D and Pulmonary Function in the Third National Health and Nutrition Examination Survey
Section snippets
Materials and Methods
A cross-sectional survey representative of the US civilian noninstitutionalized population (NHANES III) was carried out from 1988 to 1994 by the National Center for Health Statistics of the Centers for Disease Control and Prevention. A stratified, multistage sampling design was used to recruit participants from household clusters, with oversampling of non-Hispanic blacks and Mexican Americans. After an initial interview at home, participants visited mobile centers where they underwent an
Results
The adjusted mean serum concentrations of 25-hydroxyvitamin D for the main covariates are shown in Table 1. The serum 25-hydroxyvitamin D concentration was higher in men than in women, was inversely related to BMI, and declined with age. It was also lower in non-Hispanic blacks and Mexican Americans compared with non-Hispanic whites, and it was lower in participants smoking > 20 cigarettes a day compared with nonsmokers.
Table 2shows the mean (SE) FEV1 by gender, age, ethnicity, BMI, cigarette
Discussion
We have a found a dose-response relationship between the serum concentration of 25-hydroxyvitamin D and FEV1. Even after adjustment for age, gender, ethnicity, height, and smoking, all of which can affect lung function, and for BMI, which can affect both lung function and vitamin D concentrations, the mean difference between the lowest quintile of 25-hydroxyvitamin D and the next quintile was 79 mL. This increased to 126 mL when the lowest and highest quintiles were compared. The difference in
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The authors have received funding from the Health Research Council of New Zealand.