Chest
Volume 126, Issue 4, Supplement, October 2004, Page 889S
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Poster Presentations
Inhibition of Bleomycin-Induced Pulmonary Fibrosis by Okam Extract J201

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Abstract

PURPOSE: To explore the inhibitory effect of okam extract J201 on bleomycin-induced pulmonary fibrosis and its underlying mechanism of action.

METHODS: Inhibition of proliferation and collagen synthesis of human lung fibroblast by okam extract J201 and its effect on PDGF were measured by MTT assay and Sircol Soluble Collagen Assay in vitro. Using bleomycin-induced pulmonary fibrosis animal model, its effects on mouse lung index, concentration of serum IL-4, INF-r were measured with ELISA. The

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