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Annual Review of Pathology: Mechanisms of Disease

Volume 7, 2012

Review Article

Psoriasis

Gayathri K. Perera¹, Paola Di Meglio¹, and Frank O. Nestle¹
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Affiliations: St. John's Institute of Dermatology, King's College London, London SE1 9RT, United Kingdom; email: [email protected], [email protected], [email protected] National Institute for Health Research Biomedical Research Centre, Guy's and St. Thomas's Hospitals, London SE1 9RT, United Kingdom
Vol. 7:385-422 (Volume publication date February 2012) https://doi.org/10.1146/annurev-pathol-011811-132448
First published as a Review in Advance on November 04, 2011
© Annual Reviews

Abstract

Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis. We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies.

Keyword(s): biologics, cytokines, immunopathogenesis, keratinocytes, lymphocytes, PSORS

[Erratum, Closure]

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2012-02-28

2024-04-16

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Psoriasis

Annual Review of Pathology: Mechanisms of Disease 7, 385 (2012); https://doi.org/10.1146/annurev-pathol-011811-132448

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Article Type: Review Article

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