The Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) Study: Rationale and Methods

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BACKGROUND AND RATIONALE FOR THE CORAL STUDY

Despite the increase in renal artery interventional procedures for the treatment of atherosclerotic renal artery stenosis (RAS) in the United States (1), the clinical advantages of revascularization with angioplasty have not been proved, and the outcomes of patients with RAS treated by rigorous medical intervention alone have not been systematically evaluated. Randomized clinical trials comparing percutaneous transluminal renal angioplasty (PTRA) without stent placement with medical therapy

Acknowledgments

The authors thank Dr. Diane Reid of the National Heart Lung and Blood Institute for her insightful comments during preparation of this manuscript. This work was supported in part by a grant from the National Heart, Lung, and Blood Institute, grant number HL071556-01.

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    Supported in part by the National Heart, Lung, and Blood Institute, Cordis Endovascular (Warren, NJ) and Astra Zeneca (London, UK). None of the authors have identified a potential conflict of interest.

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