The interval between menarche and age of first sexual intercourse as a risk factor for subsequent HPV infection in adolescent and young adult women

doi:10.1067/mpd.2002.128893

The Journal of Pediatrics

Volume 141, Issue 5, November 2002, Pages 718-723

https://doi.org/10.1067/mpd.2002.128893 Get rights and content

Abstract

We sought to determine whether the interval between menarche and age of first sexual intercourse is associated with subsequent human papilloma virus (HPV) infection and if so, whether the association is independent of the age of first sexual intercourse. Female university students completed a survey and were screened for cervicovaginal HPV infection. HPV-positive subjects were matched to HPV-negative subjects (n = 504). Mean subject age was 20.4 ± 2.1 years, age of first sexual intercourse 16.7 ± 1.8 years, and interval 4.4 ± 2.0 years. The interval was associated with HPV infection, but the association became nonsignificant in univariate stratified analyses and multivariate models estimating the association between the interval and HPV infection. A short interval is associated with HPV infection, but the association is not independent of age of first sexual intercourse. Age of first sexual intercourse should be considered an important and identifiable risk factor for subsequent HPV infection in research and clinical settings. (J Pediatr 2002;141:718-23)

Section snippets

Study ppulation

The study population consisted of female students enrolled at Rutgers University, who were invited to participate in a longitudinal study examining the natural history of cervicovaginal HPV infection. Details of recruitment have been described previously.⁹ Informed consent was obtained from all subjects, and institutional review board approval was obtained in compliance with human experimentation guidelines of the US Department of Health and Human Services. Eligibility criteria included first

Results

Characteristics of the entire study population have been described previously.1, 9 Self-reported race/ethnicity was as follows: 59% white, 12% black, 13% Hispanic, 9% Asian, and 7% other. Mean subject age was 20.4 ± 2.1 years, mean age of menarche 12.3 ± 1.2 years, mean age of first sexual intercourse 16.7 ± 1.8 years, and the mean interval between menarche and age of first sexual intercourse 4.4 ± 2.0 years. Mean lifetime number of sexual partners was 4.2 ± 3.9 and mean number of sexual

Discusssion

Several previous studies have explored whether the interval between menarche and age of first sexual intercourse predicts HPV infection, other STI, and CIN.10, 11, 12 Shew et al¹¹ reported that the interval between menarche and age of first sexual intercourse was significantly shorter for HPV-infected versus noninfected adolescents, suggesting that the interval is an important risk factor for HPV infection in that it reflects cervical immaturity. Moscicki et al¹⁰ found that those subjects with

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Human Papillomavirus genotypes distribution and associated risk factors among women living in Southern Morocco
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The aim of this work was to investigate potential risk factors associated with HPV infection and to determine the HPV genotype prevalence among women from the Southerns areas of Morocco.
A total of n = 308 sexually active women provided their written consent to participate in this study. A detailed questionnaire was used to collect data, related to the age and life style of participants. HPV L1 gene detection was performed by a nested PCR method using consensus primers. HPV genotypes were determined using direct Sanger sequencing method. Statistical analysis of the results obtained was carried out using R software.
We detected HPV in 42.5 % of the total investigated samples. HPV infection was significantly associated with the following risk factors: age of the first intercourse (OR = 2.27, 95 % CI: 1.03–5.10, p = 0.044), and previous history of STIs (OR = 3.13, 95 % CI: 1.12–9.63, p = 0.034). High risk-HPV and Low risk-HPV genotypes were found in 26.6 % and 5.5 % of the participants, respectively. The most prevalent genotypes were HPV16 (22 %), HPV18 (2.6 %), HPV11 (1.6 %) and HPV83 (1.3 %). Multiple infections were found in 3.2 %. The genotypes covered by the bivalent, quadrivalent and nonavalent HPV vaccines account for 57.5 %, 62.8 % and 66.6 %, respectively.
HPV infection prevalence reported in this study among women from the Southerns areas of Morocco is one of the highest reported in the country so far. Our finding confirm that the current HPV vaccines directed against the most prevalent HPV16 genotype, recently introduced in the country, should offer a good protection to the most vulnerable population if implemented properly. These results highlight the importance of HPV screening and vaccination programs in this region.
Transitions in body and behavior: A meta-analytic study on the relationship between pubertal development and adolescent sexual behavior
2015, Journal of Adolescent Health
The present meta-analysis studies the relations of pubertal timing and status with sexual behavior and sexual risk behavior among youth aged 10.5–22.4 years. We included biological sex, age, and ethnicity as potential moderators. Four databases were searched for studies (published between 1980 and 2012) on the relation between pubertal timing or status and sexual behavior. The outcomes were (1) sexual intercourse; (2) combined sexual behavior; and (3) risky sexual behavior. Earlier pubertal timing or more advanced pubertal status was related to earlier and more sexual behavior, and earlier pubertal timing was related to more risky sexual behavior. Further, the links between (1) pubertal status and combined sexual behavior and (2) pubertal timing and sexual intercourse status, combined sexual behavior, and risky sexual behavior were stronger for girls than boys. Most links between pubertal status, timing, and sexual behavior and sexual risk behavior were stronger for younger adolescents. Moderation by ethnicity did not yield consistent results. There was significant variation in results among studies that was not fully explained by differences in biological sex, age, and ethnicity. Future research is needed to identify moderators that explain the variation in effects and to design sexual health interventions for young adolescents.
"U" shape of age-specific prevalence of high-risk human papillomavirus infection in women attending hospitals in Shanghai, China
2009, European Journal of Obstetrics and Gynecology and Reproductive Biology
Citation Excerpt :
This suggests that HPV triage is a useful method for young women with ASC-US so that fewer women would be referred for colposcopic evaluation [18,19]. Earlier sexual debut is a risk factor for HPV infection [14,20]. Licensed by the U.S. Food and Drug Administration, the quadrivalent HPV vaccine has been used in clinical trials which indicate that the vaccine has high efficacy in preventing persistent HPV infection, cervical cancer precursor lesions, vaginal and vulvar cancer precursor lesions, and genital warts caused by HPV types 6, 11, 16 or 18 among females who have not already been infected with the respective HPV type.
The purpose of the present study was to estimate the prevalence of high-risk human papillomavirus infection and the viral load in different age groups, to describe the distribution of human papillomavirus prevalence in women enrolled in two hospitals.
We retrospectively investigated 17,148 cases undergoing hybrid capture II between January 2005 and February 2007. The prevalence of human papillomavirus infection and the level of viral load were estimated in different age groups to describe the distribution in the cases.
Human papillomavirus was detected in 5173 of 17,148 women (30.2%) aged 17–79 years. The highest prevalence appeared in the ≤20-year age group (45.2%). After age 20, the prevalence declined rapidly and then ascended slowly from 28.5% in the 21–30-year age group to 38.0% in the ≥61-year group. The mean viral load was 294.12 ± 511.66 relative light units/positive control in total human papillomavirus positive cases. The viral load of the 21–30-year age group was the lowest (271.99 ± 499.24 relative light units/positive control) and the highest was found in the ≥61-year interval (560.30 ± 672.87 relative light units/positive control). No significant correlation was found between viral load and the severity of cervical lesions.
Our study showed a “U” shape of age-specific prevalence of high-risk human papillomavirus infection occurring in women attending hospitals in Shanghai, China, similar to worldwide figures.
Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women
2021, Scientific Reports
Risk factors for non-human papillomavirus (HPV) Type 16/18 cervical infections and associated lesions among HPV DNA-negative women vaccinated against HPV-16/18 in the Costa Rica Vaccine Trial
2021, Journal of Infectious Diseases
Human papillomavirus genotype distribution and factors associated among female sex workers in West Africa
2020, PLoS ONE

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^☆: Data collection was supported by a grant from the National Institutes of Health. DNA oligonucleotides were synthesized in the Oligo Synthesis facility of the Albert Einstein Cancer Center. Dr Ho is the recipient of a Junior Faculty Research Award, and Dr Burk is the recipient of a Faculty Research Award, both from the American Cancer Society. Dr Kahn was supported by Project No. 5 T71 MC 00001-24 from the Maternal-Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Resources.

^☆☆: Reprint requests: Jessica A. Kahn, MD, MPH, Division of Adolescent Medicine, Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229.

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Clinical and Laboratory ObservationsThe interval between menarche and age of first sexual intercourse as a risk factor for subsequent HPV infection in adolescent and young adult women☆,☆☆

Abstract

Section snippets

Study ppulation

Results

Discusssion

Pediatr Clin North Am

J Pediatr

J Pediatr

J Pediatr

Lancet

Am J Obstet Gynecol

J Clin Epidemiol

Am J Obstet Gynecol

Ann Epidemiol

Am J Obstet Gynecol

J Adolesc Health

Obstet Gynecol

J Clin Epidemiol

Natural history of cervicovaginal Papilloma virus infection in young women

N Engl J Med

Human papilloma virus is a necessary cause of invasive cervical cancer worldwide

J Pathol

Type-specific persistence of human papilloma virus DNA before the development of invasive cervical cancer

N Engl J Med

A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papilloma virus infection

N Engl J Med

Determinants of genital Human Papilloma virus infection in young women

J Natl Cancer Inst

Cervical intraepithelial neoplasia: the role of age at first coitus in its etiology

J Reprod Med

Sexual behavior and partner characteristics are the predominant risk factors for genital human Papilloma virus infection in young women

J Infect Dis

Clinical and Laboratory Observations
The interval between menarche and age of first sexual intercourse as a risk factor for subsequent HPV infection in adolescent and young adult women☆,☆☆