Outcomes, Health Policy, and Managed CareHematocrit and the risk of coronary heart disease mortality☆
Section snippets
Methods
The National Center for Health Statistics of the Centers for Disease Control and Prevention conducted NHANES II between February 1976 and February 1980. NHANES II, a nationwide probability sample of approximately 28,000 persons, was designed to be representative of the civilian, noninstitutionalized population of the United States aged 6 months to 74 years. A detailed description of the NHANES II survey and sampling procedures has been provided elsewhere.20
Briefly, data were collected through
Results
The mean Hct for men (44.1, SE 0.07) and women (40.1, SE 0.08) differed significantly (P <.01), suggesting 2 different underlying distributions of Hct for the sex groups. Therefore baseline characteristics by Hct are shown in Table I separately for men and women.Empty Cell Men Women Hct 19.0-43.0 (n = 1629) Hct 43.2-45.2 (n = 1220) Hct 45.5-61.7 (n = 1364) Hct 14.5-39.0 (n = 1706) Hct 39.2-41.5 (n = 1528) Hct
Discussion
Consistent with the findings of previous studies, our results indicate that elevated Hct is associated with several CVD risk factors, including cigarette smoking, blood pressure, and total cholesterol. In addition, the association between Hct and mortality is different for men and women. Crude mortality rates among men suggest a nonlinear relationship between Hct and mortality from CHD, diseases of the heart, and all causes; however, these associations were not apparent after adjustment for CVD
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Reprint requests: Wayne H. Giles, MD, MSc, Cardiovascular Health Branch, CDC/NCCDPHP (MS K-47), 4770 Buford Hwy NE, Atlanta, GA 30341-3717. E-mail: [email protected]