Original InvestigationDialysisRepeated Peritoneal Dialysis–Associated Peritonitis: A Multicenter Registry Study
Section snippets
Study Population
The study included all Australian adult patients from ANZDATA who were receiving PD between October 1, 2003 (when detailed peritonitis data started to be collected), and December 31, 2007. Data collected included demographic data, cause of primary kidney disease, comorbid conditions at the start of dialysis therapy, smoking status, body mass index, late referral (defined as start of dialysis therapy within 3 months of referral to a nephrologist), microbiology of peritonitis episodes (up to 3
Population Characteristics
A total of 6,024 patients received PD in Australia during the study period (October 1, 2003, to December 31, 2007). They were followed up for 9,330 patient-years (mean follow-up, 1.55 years/patient). In this group, 4,864 episodes of peritonitis occurred in 2,542 (42%) patients and more than one episode of peritonitis occurred in 1,171 patients (range, 2-15 episodes/patient). A total of 485 episodes of repeated peritonitis (10% of all peritonitis episodes) occurred in 348 patients and 1,399
Discussion
To our knowledge, our study is the most extensive report published of the frequency, predictors, treatment, and clinical outcomes of PD-associated repeated peritonitis. Compared with nonrepeated episodes, repeated peritonitis episodes were significantly more likely to occur earlier after a prior peritonitis episode and to be complicated by relapse, but less likely to be cured with antibiotic therapy alone and less likely to be complicated by hospitalization. Rates of catheter removal, transfer
Acknowledgements
We acknowledge the substantial contributions of the entire Australia and New Zealand nephrology community (physicians, surgeons, database managers, nurses, renal operators, and patients) in providing information for and maintaining the ANZDATA database.
Support: None.
Financial Disclosure: Dr Johnson is a consultant for Baxter Healthcare Pty Ltd and has previously received research funds from this company; he has also received speakers' honoraria and research grants from Fresenius Medical Care.
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Originally published online August 17, 2011.