Original InvestigationPathogenesis and Treatment of Kidney DiseaseModification of the CKD Epidemiology Collaboration (CKD-EPI) Equation for Japanese: Accuracy and Use for Population Estimates
Section snippets
Participants
To perform a diagnostic test study to compare the modified CKD-EPI and modified MDRD Study equations, we used same data sets from which the Japanese coefficient of the MDRD Study equation was developed and validated. Details of participants were reported previously.3 Briefly, 763 Japanese patients in 80 medical centers were included. They were divided into a development data set (413 participants) and a validation data set (350 participants). GFR was measured using inulin renal clearance. Serum
Modifying the CKD-EPI Equation for a Japanese Population
The coefficient to modify the CKD-EPI equation for Japanese, calculated from the development data set of 413 participants (for whom clinical characteristics are listed in Table 1), was found to be 0.813 (95% confidence interval, 0.794-0.833).
Diagnostic Test Study
We used a diagnostic test design to compare the Japanese coefficient–modified CKD-EPI and MDRD Study equations, which are listed in Table 2.
Discussion
We previously reported a Japanese coefficient of 0.808 for the MDRD Study equation.3 In the present study, we obtained the Japanese coefficient of 0.813 (95% confidence interval, 0.794-0.833) for the CKD-EPI equation. The values are similar in both equations. The observation that correction coefficients are less than 1.0 indicates lower serum creatinine levels in Japanese than in whites with equivalent GFRs, probably because of the lower skeletal muscle mass found in Japanese compared with
Acknowledgements
Support: This study was supported by a grant from the Japanese Society of Nephrology.
Financial Disclosure: The authors declare that they have no relevant financial interests.
References (5)
- et al.
Revised equations for estimating glomerular filtration rate (GFR) from serum creatinine in Japan
Am J Kidney Dis
(2009) - et al.
Assessing kidney function
N Engl J Med
(2006)
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Originally published online as doi:10.1053/j.ajkd.2010.02.344 on April 23, 2010.