Original InvestigationPathogenesis and Treatment of Kidney DiseaseAssociation of Uric Acid With Change in Kidney Function in Healthy Normotensive Individuals
Section snippets
Methods
Between May and October 2003, a total of 900 apparently healthy persons (153 women, 747 men) with an age range of 20-65 years were recruited from blood donors at our hospital transfusion center after excluding those with known diabetes and/or hypertension, nephropathies (such as glomerulonephritis, pyelonephritis, hereditary kidney disease, and kidney stones), gout, or positive history of cardiovascular disease (stroke, transitory ischemic attacks, coronary heart disease, and peripheral
Results
Uric acid quartile-specific demographic, clinical, and biochemical parameters of participants studied at baseline and completion of the study are listed in Table 1 for women and Table 2 for men. eGFR decreased to <60 mL/min/1.73 m2 in 12 participants (11 men, 1 woman) according to the MDRD Study equation and in 11 (10 men, 1 woman) according to the CKD-EPI equation. No study participant developed gout and/or diabetes during follow-up, 4 developed impaired fasting glucose levels, and 17 (13 men,
Discussion
Results of our study show that even in a sample of healthy persons, GFR decreases over time, and uric acid level is an independent risk factor for such a decrease. The eGFR decrease observed in our study was larger than expected compared with previous population studies from Asia, Europe, and the United States30, 31, 32; such a finding may be explained in part by a regression to the mean phenomenon after exclusion from the study of persons with increased serum creatinine levels and in part by
Acknowledgements
Support: None.
Financial Disclosure: The authors declare that they have no relevant financial interests.
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2023, European Journal of Internal MedicineUrate Transporter ABCG2 Function and Asymptomatic Hyperuricemia: A Retrospective Cohort Study of CKD Progression
2023, American Journal of Kidney DiseasesCitation Excerpt :We also found that ≤50% function of ABCG2 was associated with accelerated eGFR decline when compared with fully functional ABCG2 (P = 0.02 for interaction) (Fig 3B). Numerous observational studies have investigated the association between SUA and kidney function; many of the results suggest that elevated SUA is predictive of poor kidney prognosis.11,12,15,18-20 However, observational studies are often limited by bias and confounding and are not suitable for inferring causality.
The effect of dapagliflozin on uric acid excretion and serum uric acid level in advanced CKD
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Originally published online as doi:10.1053/j.ajkd.2010.01.019 on April 12, 2010.