Original InvestigationPathogenesis and Treatment of Kidney DiseaseComparison of the Prevalence and Mortality Risk of CKD in Australia Using the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study GFR Estimating Equations: The AusDiab (Australian Diabetes, Obesity and Lifestyle) Study
Section snippets
Participants
AusDiab is a population-based survey of adults aged ≥ 25 years. The present report uses cross-sectional data collected at baseline (1999/2000). Details of survey methods and sample selection have been described previously in detail.20 In brief, a representative sample of the population was obtained using a stratified cluster sampling method. Of 17,130 households eligible for inclusion, 11,579 agreed to be interviewed and 20,386 adults completed the household interview. A total of 11,247
Results
Of 11,247 individuals who presented for physical examination at baseline, complete data for kidney function (serum creatinine level, urine albumin-creatinine ratio, and urine protein-creatinine ratio) were available for 99.4% (n = 11,182). Participants were predominantly white (92.9%), with a minority of Asian (5.70%) and indigenous (0.80%) participants. Mean age of participants was 51.5 ± 14.5 (standard deviation [SD]) years and 55.2% were women. Table 1 lists the distribution of CKD stages in
Discussion
The MDRD Study equation has gained widespread acceptance in research and clinical practice in recent years and has been validated in diverse populations.18 Developed based on 1,628 patients with existing CKD, the MDRD Study equation provides accurate estimates across a wide range of subgroups for GFR < 60 mL/min/1.73 m2. However, a well-recognized limitation of this equation is the systematic underestimation of GFR when measured GFR is near or > 60 mL/min/1.73 m2. The CKD-EPI equation,
Acknowledgements
The AusDiab Kidney Study is a substudy of the AusDiab Study.
Support: In addition to support from the AusDiab co-coordinating team led by Professor Paul Zimmet and Associate Professor Jonathan Shaw at the Baker IDI Heart and Diabetes Institute, Melbourne, Australia, their sponsors, and the National Health and Medical Research Council of Australia (NHMRC grant 233200), the AusDiab Kidney Study specifically acknowledges the support of Amgen Australia, Kidney Health Australia, and The Royal Prince
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Originally published online as doi:10.1053/j.ajkd.2009.12.011 on February 8, 2010.