Original InvestigationPathogenesis and Treatment of Kidney DiseaseLong-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis
Section snippets
Methods
This study was performed in accordance with published guidelines for systematic review, analysis, and reporting for meta-analyses of observational studies.21
Results
We identified 3,808 citations meeting our search criteria. After excluding 689 duplicate citations, 3,119 abstracts were evaluated, and 419 articles were selected for further review (Fig 1). Reasons for exclusion are shown in Fig 1. Forty-eight articles were deemed eligible for this systematic review.22, 23, 24, 25, 26, 27, 28, 29, 30, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
Study and
Discussion
This study shows that patients who survive AKI have a greater rate of long-term mortality and other adverse outcomes than patients who survive hospitalization without AKI. The associations were consistent in every clinical setting. With increasing severity of AKI, the association between AKI and death was even stronger, and the association with long-term mortality seemed to be present even in patients with more rapidly reversible AKI. These findings expand on results from our previous
Acknowledgements
Support: Dr Coca is funded by the career development grant K23DK08013 from the National Institutes of Health and is supported by the American Heart Association's Established Investigator Award. Dr Garg is funded by the Clinical Scientist Award from the Canadian Institutes of Health Research. Dr Parikh is supported by the AKI grants RO1 HL085757 and UO1-DK082185 from the National Institutes of Health.
Financial Disclosure: None.
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Social isolation, loneliness, and the risk of incident acute kidney injury in middle-aged and older adults: A prospective cohort study
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2024, Kidney International ReportsAdult Cardiac Surgery-Associated Acute Kidney Injury: Joint Consensus Report
2023, Journal of Cardiothoracic and Vascular AnesthesiaIntegrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes
2023, American Journal of Kidney Diseases
Originally published online as doi:10.1053/j.ajkd.2008.11.034 on April 6, 2009.
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