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Predictors for cod-liver oil supplement use — the Norwegian Women and Cancer Study

Abstract

Objective: To assess the use of cod-liver oil supplements among Norwegian women and to examine dietary, lifestyle, demographic, and health factors associated with use of this supplement.

Design: Cross-sectional study.

Setting and subjects: The study is based on data from a food frequency questionnaire from 1998 answered by 37 226 women aged 41–55 y, who in 1991/1992 participated in the Norwegian component of the European Prospective Investigation into Cancer and Nutrition (EPIC). The Norwegian EPIC cohort was based on a random nation-wide sample of Norwegian women.

Results: Cod-liver oil supplement use was reported by 44.7% of the participating women. Subjects with higher education, high physical activity level, and body mass index (BMI) in the normal range were more likely to use cod-liver oil supplements. Consumption did also increase with increased age as well as with increased reported consumption of fruits, vegetables, fatty fish, lean fish, and vitamin D (excluding the vitamin D contribution from cod-liver oil). Energy intake was higher among cod-liver oil users than nonusers. Whole-year daily users of cod-liver oil were also more likely to take other dietary supplements (OR=2.45, 95% CI: 2.28–2.62). Never smokers were more likely to use cod-liver oil supplements than current smokers.

Conclusion: Use of cod-liver oil is associated with several sociodemographic factors, self-reported health issues, and intake of fish, fruit, and vegetables. When assessing the relationship between cod-liver oil use and occurrence of chronic diseases potential confounders need to be considered. Cod-liver oil use seemed not to be matched with vitamin D needs. Thus, emphasis on assessing vitamin D status by measuring levels in blood should be investigated further, in particular, among people living in northern latitudes.

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References

  • Andersen LF, Nes M, Bjorneboe GEA & Drevon CA (1997): Food habits among 13-year-old Norwegian adolescents. Scand. J. Nutr./Näringsforsk. 41, 150–154.

    Google Scholar 

  • Balluz LS, Kieszak SM, Philen RM & Mulinare J (2000): Vitamin and mineral supplement use in the United States. Results from the third National Health and Nutrition Examination Survey. Arch. Fam. Med. 9, 258–262.

    Article  CAS  Google Scholar 

  • Bristow A, Qureshi S, Rona RJ & Chinn S (1997): The use of nutritional supplements by 4–12 year olds in England and Scotland. Eur. J. Clin. Nutr. 51, 366–369.

    Article  CAS  Google Scholar 

  • Brustad M, Sandanger T, Wilsgaard T, Aksnes, L & Lund E (2003): Change in plasma levels of vitamin D after consumption of ‘Mølje’ (cod, cod-liver, fresh cod-liver oil, and hard roe)-a traditional north Norwegian fish dish. Int. J. Circumpolar Health, 62, 40–53.

    Article  Google Scholar 

  • Dorant E, van-den-Brandt PA, Hamstra AM, Feenstra MH, Goldbohm RA, Hermus RJ & Sturmans F (1993): The use of vitamins, minerals and other dietary supplements in The Netherlands. Int. J. Vitam. Nutr. Res. 63, 4–10.

    CAS  PubMed  Google Scholar 

  • Dwyer JT, Garcea AO, Evans M, Li D, Lytle L, Hoelscher D, Nicklas TA & Zive M (2001): Do adolescent vitamin–mineral supplement users have better nutrient intakes than non-users? Observations from the CATCH tracking study. J. Am. Diet. Assoc. 101, 1340–1346.

    Article  CAS  Google Scholar 

  • Egeland GM, Meyer HE, Selmer R, Tverdal A & Vollset SE (2001): Cod-liver oil consumption, smoking, and coronary heart disease mortality: three counties, Norway. Int. J. Circumpolar Health 60, 143–149.

    CAS  PubMed  Google Scholar 

  • Ervin RB, Wright JD & Kennedy-Stephenson J (1999): Use of dietary supplements in the United States, 1988–94. Vital. Health Stat. 11, 1–14.

    Google Scholar 

  • Frank E, Bendich A & Denniston M (2000): Use of vitamin–mineral supplements by female physicians in the United States. Am. J. Clin. Nutr. 72, 969–975.

    Article  CAS  Google Scholar 

  • Hjartaker A & Lund E (1998): Relationship between dietary habits, age, lifestyle, and socio-economic status among adult Norwegian women. The Norwegian Women and Cancer Study. Eur. J. Clin. Nutr. 52, 565–572.

    Article  CAS  Google Scholar 

  • Hjartaker A, Lund E & Bjerve KS (1997): Serum phospholipid fatty acid composition and habitual intake of marine foods registered by a semi-quantitative food frequency questionnaire. Eur. J. Clin. Nutr. 51, 736–742.

    Article  CAS  Google Scholar 

  • Johansson L, Drevon CA & Aa Bjorneboe GE (1996): The Norwegian diet during the last hundred years in relation to coronary heart disease. Eur. J Clin. Nutr. 50, 277–283.

    CAS  PubMed  Google Scholar 

  • Johansson L & Solvoll (1999): Norkost 1997 — Landsomfattende kostholdsundersøkelse blant menn og kvinner i alderen 16–79 år. Oslo: Statens råd for ernæring og fysisk aktivitet.

    Google Scholar 

  • Johansson LR, Solvoll K, Bjorneboe GE & Drevon CA (1998): Intake of very-long-chain n-3 fatty acids related to social status and lifestyle. Eur. J. Clin. Nutr. 52, 716–721.

    Article  CAS  Google Scholar 

  • Johansson L, Solvoll K, Bjorneboe GE & Drevon CA (1997): Dietary habits among Norwegian men and women. Scand. J. Nutr./Näringsforsk. 41, 63–70.

    Google Scholar 

  • Kaartinen P, Ovaskainen ML & Pietinen P (1997): The use of dietary supplements among Finnish adults. Scand. J. Nutr./Näringsforsk. 41, 13–17.

    Google Scholar 

  • Kloster J (1931): The distribution and frequency of rickets in one of the fishery districts of Finnmark and relation of diet to the disorder. Acta Paediatr. 12 (Suppl 3), S1–S82.

    Google Scholar 

  • Koplan JP, Annest JL, Layde PM & Rubin GL (1986): Nutrient intake and supplementation in the United States (NHANES II). Am. J. Public Health 76, 287–289.

    Article  CAS  Google Scholar 

  • Lehtonen Veromaa M, Mottonen T, Irjala K, Karkkainen M, Lamberg-Allardt C, Hakola P & Viikari J (1999): Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls. Eur. J. Clin. Nutr. 53, 746–751.

    Article  CAS  Google Scholar 

  • Lyle BJ, Mares-Perlman JA, Klein BE, Klein R & Greger JL (1998): Supplement users differ from non-users in demographic, lifestyle, dietary and health characteristics. J. Nutr. 128, 2355–2362.

    Article  CAS  Google Scholar 

  • Maxwell SR (1999): Antioxidant vitamin supplements: update of their potential benefits and possible risks. Drug Saf. 21, 253–266.

    Article  CAS  Google Scholar 

  • Messerer M, Johansson SE & Wolk A (2001a): Use of dietary supplements and natural remedies increased dramatically during the 1990s. J. Intern. Med. 250, 160–166.

    Article  CAS  Google Scholar 

  • Messerer M, Johansson SE & Wolk A (2001b): Sociodemographic and health behaviour factors among dietary supplement and natural remedy users. Eur. J. Clin. Nutr. 55, 1104–1110.

    Article  CAS  Google Scholar 

  • Patterson RE, White E, Kristal AR, Neuhouser ML & Potter JD (1997): Vitamin supplements and cancer risk: the epidemiologic evidence. Cancer Causes Control 8, 786–802.

    Article  CAS  Google Scholar 

  • Pedersen JI, Johansson L, Frølich W, Nordgård H & Trygg K (1995): Assessment of the need for food fortification in Norway. Scand. J. Nutr/Näringsforsk 39, 84–87.

    Google Scholar 

  • Rimestad AH, Borgejordet Å, Vesterhus KN, Sygnestveit K, Løken EB, Trygg K, Pollestad ML, Lund-Larsen K, Omholt-Jensen G & Nordbotten A (2001): Den store matvaretabellen. Oslo: Gyldendal.

    Google Scholar 

  • Sandström B, Aro A, Becker W, Lyhne N, Pedersen JI & Pórsdóttir I (1996): Nordiska näringsrekommendationer 1996. Köpenhamn: Nordiska Ministerrådet.

    Google Scholar 

  • Slesinski MJ, Subar AF & Kahle LL (1996): Dietary intake of fat, fiber and other nutrients is related to the use of vitamin and mineral supplements in the United States: the 1992 National Health Interview Survey. J. Nutr. 126, 3001–3008.

    Article  CAS  Google Scholar 

  • Troppmann L, Gray-Donald K & Johns T (2002): Supplement use: is there any nutritional benefit? J. Am. Diet. Assoc. 102, 818–825.

    Article  Google Scholar 

  • Webb AR & Holick MF (1988): The role of sunlight in the cutaneous production of vitamin D3. Annu. Rev. Nutr. 8, 375–399.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was carried out with support from the Research Council of Norway. We thank Guri Skeie (Institute of Community Medicine, University of Tromsø, Norway) for carrying out the nutrition calculations, Elin Alsaker (Institute of Community Medicine, University of Tromsø, Norway) for helping with the computer programming, and Professor Evert Nieboer (McMaster University, Hamilton, ON, Canada) for revising the English language.

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Guarantor: M Brustad.

Contributors: MB wrote the paper and performed the statistical analysis. TB supervised the statistical analysis and contributed to the writing of the paper. EL was the principal investigator.

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Correspondence to M Brustad.

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Brustad, M., Braaten, T. & Lund, E. Predictors for cod-liver oil supplement use — the Norwegian Women and Cancer Study. Eur J Clin Nutr 58, 128–136 (2004). https://doi.org/10.1038/sj.ejcn.1601759

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