Late presentation to hepatitis B virus and hepatitis C virus care is common, hindering global efforts to reduce the morbidity and mortality associated with liver disease. Models of care promoting and simplifying early testing of viral hepatitis are needed if we are to eliminate viral hepatitis as a major public health threat by 2030.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Kairos in diagnostics
Theoretical Medicine and Bioethics Open Access 07 February 2024
-
A cascade of care analysis on the elimination of hepatitis C from public hospitals in Madrid
Communications Medicine Open Access 24 February 2022
-
Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review
Scientific Reports Open Access 17 December 2021
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
World Health Organization. Global Hepatitis Report, 2017. WHO http://apps.who.int/iris/bitstream/10665/255016/1/9789241565455-eng.pdf?ua=1 (2017).
GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390, 1151–1210 (2017).
Rodger, A. J. et al. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA 316, 171–181 (2016).
Crespo, G. et al. The efficacy of direct anti-HCV drugs improves early post-liver transplant survival and induces significant changes in waiting list composition. J. Hepatol. 69, 11–17 (2018).
Mauss, S. et al. Late presentation of chronic viral hepatitis for medical care: a consensus definition. BMC Med. 15, 92 (2017).
Cortesi, P. A. et al. Systematic review: economic evaluations of HCV screening in the direct-acting antivirals era. Aliment. Pharmacol. Ther. 49, 1126–1133 (2019).
Grebely, J. et al. Hepatitis C point-of-care diagnostics: in search of a single visit diagnosis. Expert Rev. Mol. Diagn. 17, 1109–1115 (2017).
Fuglsang Hansen, J. et al. Late presentation for care among patients with chronic hepatitis C: prevalence and risk factors. Open Forum Infect. Dis. 5, ofx257 (2017).
Bischoff, J. et al. Has increased rollout of direct acting antiviral therapy decreased the burden of late presentation and advanced liver disease in patients starting hepatitis C virus therapy in Germany? J. Clin. Gastroenterol. https://doi.org/10.1097/MCG.0000000000001189 (2019).
Sangiovanni, A. et al. The natural history of compensated cirrhosis due to hepatitis C virus: a 17-year cohort study of 214 patients. Hepatology 43, 1303–1310 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Lazarus, J.V., Picchio, C., Dillon, J.F. et al. Too many people with viral hepatitis are diagnosed late — with dire consequences. Nat Rev Gastroenterol Hepatol 16, 451–452 (2019). https://doi.org/10.1038/s41575-019-0177-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41575-019-0177-z
This article is cited by
-
Kairos in diagnostics
Theoretical Medicine and Bioethics (2024)
-
Screening strategy to advance HCV elimination in Italy: a cost-consequence analysis
The European Journal of Health Economics (2024)
-
A cascade of care analysis on the elimination of hepatitis C from public hospitals in Madrid
Communications Medicine (2022)
-
Factors associated with testing for HIV and hepatitis C among behaviorally vulnerable men in Germany: a cross-sectional analysis upon enrollment into an observational cohort
AIDS Research and Therapy (2021)
-
A novel model of care for simplified testing of HBV in African communities during the COVID-19 pandemic in Spain
Scientific Reports (2021)