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Proteostasis and aging

Nature Medicine volume 21, pages 1406–1415 (2015)Cite this article

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Abstract

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved understanding of the systems that contribute to cellular protein quality control has shed light on the reasons for the increased vulnerability of the proteome to stress in aging cells. Maintenance of protein homeostasis, or proteostasis, is attained through precisely coordinated systems that rapidly correct unwanted proteomic changes. Here we focus on recent developments that highlight the multidimensional nature of the proteostasis networks, which allow for coordinated protein homeostasis intracellularly, in between cells and even across organs, as well as on how they affect common age-associated diseases when they malfunction in aging.

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Figure 1: Changes with age in intracellular proteostasis systems.

Debbie Maizels/Nature Publishing Group

Figure 2: Organelle proteostasis networks.

Debbie Maizels/Nature Publishing Group

Figure 3: Schematic of possible mediators of intercellular proteostasis: exosomes and nanotubes.

Debbie Maizels/Nature Publishing Group

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  1. Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, New York, New York, USA

    Susmita Kaushik & Ana Maria Cuervo

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Correspondence to Ana Maria Cuervo.

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Kaushik, S., Cuervo, A. Proteostasis and aging. Nat Med 21, 1406–1415 (2015). https://doi.org/10.1038/nm.4001

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