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Pre-pregnancy weight and excess weight gain are risk factors for macrosomia in women with gestational diabetes

Journal of Perinatology volume 31, pages 717–721 (2011)Cite this article

Subjects

Abstract

Objective:

To determine whether women with gestational diabetes mellitus (GDM) whose weight gain exceeded the 2009 Institute of Medicine (IOM) recommendations were more likely to have macrosomia.

Study Design:

Retrospective cohort study of the association of weight gain in women with Class A1 GDM, with term (⩾37 weeks) singleton liveborns and macrosomia (birthweight ⩾4000 g). Multivariate logistic regression models were used to adjust for covariates and test for interactions.

Result:

Of 1502 women studied, pre-pregnancy body mass index (BMI) categories were: normal (39.6%), overweight (28.5%) and obese (31.9%). The mean (±standard deviation ) weight gain (lbs) for these groups was: 27.6±10.9, 24.2±13.0 and 18.8±16.3 (P<0.0001), whereas the occurrence of macrosomia was 7.4, 11.4 and 19.0%, respectively. Women with an obese BMI were twice as likely to have a macrosomic infant compared with women in the normal BMI group (odds ratio, OR 2.0; 95% CI 1.4–3.0; P=0.0005). Independently, women who exceeded the IOM guidelines were three times more likely to have a macrosomic infant (OR 3.0, 95% CI 2.2–4.2, P<0.0001).

Conclusion:

Maternal pre-pregnancy weight and weight gain during pregnancy appear to be significant and independent risk factors for macrosomia in women with GDM.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    J G Ouzounian, G D Hernandez, L M Korst, M M Montoro & R H Lee

  2. Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Baldwin Park, CA, USA

    L R Battista & C L Walden

Authors
  1. J G Ouzounian
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  2. G D Hernandez
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  3. L M Korst
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  4. M M Montoro
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  5. L R Battista
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  6. C L Walden
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  7. R H Lee
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Correspondence to J G Ouzounian.

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Ouzounian, J., Hernandez, G., Korst, L. et al. Pre-pregnancy weight and excess weight gain are risk factors for macrosomia in women with gestational diabetes. J Perinatol 31, 717–721 (2011). https://doi.org/10.1038/jp.2011.15

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  • DOI: https://doi.org/10.1038/jp.2011.15

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