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Managing obesity in primary care practice: an overview with perspective from the POWER-UP study

Abstract

Primary care practitioners (PCPs) have been encouraged to screen all adults for obesity and to offer behavioral weight loss counseling to the affected individuals. However, there is limited research and guidance on how to provide such intervention in primary care settings. This led the National Heart, Lung and Blood Institute in 2005 to issue a request for applications to investigate the management of obesity in routine clinical care. Three institutions were funded under a cooperative agreement to undertake the practice-based opportunities for weight reduction (POWER) trials. The present article reviews selected randomized controlled trials, published before the initiation of POWER, and then provides a detailed overview of the rationale, methods and results of the POWER trial conducted at the University of Pennsylvania (POWER-UP). POWER-UP’s findings are briefly compared with those from the two other POWER trials, conducted at Johns Hopkins University and Harvard University/Washington University. The methods of delivering behavioral weight loss counseling differed markedly across the three trials, as captured by an algorithm presented in the article. Delivery methods ranged from having medical assistants and PCPs from the practices provide counseling to using a commercially available call center, coordinated with an interactive website. Evaluation of the efficacy of primary care-based weight loss interventions must be considered in light of costs, as discussed in relation to the recent treatment model proposed by the Centers for Medicare and Medicaid Services.

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References

  1. US Preventive Services Task Force. Screening for obesity in adults: recommendations and rationale. Ann Intern Med 2003; 139: 930–932.

    Article  Google Scholar 

  2. Galuska D, Will J, Serdula M, Ford E . Are health care professionals advising obese patients to lose weight? JAMA 1999; 282: 1576–1578.

    Article  CAS  Google Scholar 

  3. Yeh HC, Clark JM, Emmons KE, Moore RH, Bennett GG, Warner ET et al. Independent but coordinated trials: insights from the Practice-Based Opportunities for Weight Reduction Trials Collaborative Research Group. Clin Trials 2010; 7: 322–332.

    Article  Google Scholar 

  4. Wadden TA, Volger S, Sarwer DB, Vetter ML, Tsai AG, Berkowitz RI et al. A two-year randomized trial of obesity treatment in primary care practice. N Engl J Med 2011; 365: 1969–1979.

    Article  CAS  Google Scholar 

  5. Appel LJ, Clark JM, Yeh HC, Wang NY, Coughlin JW, Daumit G et al. Comparative effectiveness of weight-loss interventions in clinical practice. N Engl J Med 2011; 365: 1959–1968.

    Article  CAS  Google Scholar 

  6. Bennett GG, Warner ET, Glasgow RE, Askew S, Goldman J, Ritzwoller DP et al. Obesity treatment for socioeconomically disadvantaged patients in primary care practice. Arch Intern Med 2012; 172: 565–574.

    Article  Google Scholar 

  7. Moyer VA, on behalf of the US Preventive Services Task Force. Screening for and management of obesity in adults. US Preventive Services Task Force recommendation statement. Ann Intern Med 2012; 157: 373–378.

    PubMed  Google Scholar 

  8. Centers for Medicare and Medicaid Services. Decision memo for intensive behavioral therapy for obesity (CAG-00423N). Available at: http://www.cms.gov/medicare-coverage-database/details/nca-decisionmemo.aspx?&NcaName=Intensive%20Behavioral%20Therapy%20for%20Obesity&bc=ACAAAAAAIAAA&NCAId=253. Accessed December 14, 2012.

  9. National Institutes of Health/National Heart, Lung, and Blood Institute. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Obes Res 1998; 6: 51S–210S.

    Article  Google Scholar 

  10. National Heart, Lung, and Blood Institute and the North American Association for the Study of Obesity. The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. National Institutes of Health: Bethesda, MD, USA, 2000.

  11. Wadden TA, Victoria LW, Moran CH, Bailer BA . Lifestyle modification for obesity: new developments in diet, physical activity, and behavior therapy. Circulation 2012; 125: 1157–1170.

    Article  Google Scholar 

  12. Knowler WC, Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393–403.

    Article  CAS  Google Scholar 

  13. Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK, American College of Sports Medicine. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 2009; 41: 459–471.

    Article  Google Scholar 

  14. Pi-Sunyer X, Blackburn G, Brancati FL, Bray GA, Bright R, Clark JM et alLook AHEAD Research Group. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial. Diabetes Care 2007; 30: 1374–1383.

    Article  Google Scholar 

  15. Wadden TA, West DS, Neiberg RH, Wing RR, Ryan DH, Johnson KC et alLook AHEAD Research Group. One-year weight losses in the Look AHEAD study: factors associated with success. Obesity 2009; 17: 713–722.

    Article  Google Scholar 

  16. Wing RR, Look AHEAD Research Group. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care 2011; 34: 1481–1486.

    Article  CAS  Google Scholar 

  17. Wadden TA, Neiberg RH, Wing RR, Clark JM, Delahanty LM, Hill JO et alLook AHEAD Research Group. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity 2011; 19: 1987–1998.

    Article  Google Scholar 

  18. Haapala I, Barengo NC, Biggs S, Surakka L, Manninen P . Weight loss by mobile phone: a 1-year effectiveness study. Public Health Nutr 2009; 12: 2382–2391.

    Article  Google Scholar 

  19. Tate DF, Jackvony EH, Wing RR . Effects of internet behavioral counseling on weight loss in adults at risk for type 2 diabetes: a randomized trial. JAMA 2003; 289: 1833–1836.

    Article  Google Scholar 

  20. Harvey-Berino J, West D, Krukowski R, Prewitt E, VanBiervliet A, Ashikaga T et al. Internet delivered behavioral obesity treatment. Prev Med 2010; 51: 123–128.

    Article  Google Scholar 

  21. Digenio AG, Mancuso JP, Gerber RA, Dvorak RV . Comparison of methods for delivering a lifestyle modification program for obese patients: a randomized trial. Ann Intern Med 2009; 150: 255–262.

    Article  Google Scholar 

  22. Befort CA, Donnelly JE, Sullivan DK, Ellerbeck EF, Perri MG . Group versus individual phone-based obesity treatment for rural women. Eat Behav 2010; 11: 11–17.

    Article  Google Scholar 

  23. Perri MG, Limacher MC, Durning PE, Janicke DM, Lutes LD, Bobroff LB et al. Extended-care programs for weight management in rural communities: the treatment of obesity in underserved rural settings (TOURS) randomized trial. Arch Intern Med 2008; 168: 2347–2354.

    Article  Google Scholar 

  24. Kushner RF . Barriers to providing nutrition counseling by physicians: a survey of primary care practitioners. Prev Med 1995; 24: 546–552.

    Article  CAS  Google Scholar 

  25. Cohen MD, D’Amico FJ, Merestein JH . Weight reduction in obese hypertensive patients. Fam Med 1991; 23: 25–28.

    CAS  PubMed  Google Scholar 

  26. Martin PD, Rhode PC, Dutton GR, Redmann SM, Ryan DH, Brantley PJ . A primary care weight management intervention for low-income African-American women. Obesity 2006; 14: 1412–1420.

    Article  Google Scholar 

  27. Ockene IS, Hebert JR, Ockene JK, Saperia GM, Stanek E, Nicolosi R et al. Effect of physician-delivered nutrition counseling training and an office-support program on saturated fat intake, weight, and serum lipid measurements in a hyperlipidemic population: Worcester Area Trial for Counseling in Hyperlipidemia (WATCH). Arch Intern Med 1999; 159: 725–731.

    Article  CAS  Google Scholar 

  28. Wadden TA, Berkowitz RI, Womble LG, Sarwer DB, Phelan S, Cato RK et al. Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med 2005; 353: 2111–2120.

    Article  CAS  Google Scholar 

  29. Berkowitz RI, Wadden TA, Tershakovec AM, Cronquist JL . Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial. JAMA 2003; 289: 1805–1812.

    Article  CAS  Google Scholar 

  30. Apfelbaum M, Vague P, Ziegler 0, Hanotin C, Thomas F, Leutenegger E . Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine. Am J Med 1999; 106: 179–184.

    Article  CAS  Google Scholar 

  31. Hauptman J, Lucas C, Boldrin MN, Collins H, Segal KR . Orlistat in the long-term treatment of obesity in primary care settings. Arch Fam Med 2000; 9: 160–167.

    Article  CAS  Google Scholar 

  32. Brownell KD, Wadden TA . The LEARN Program for Weight Control: Special Medication Edition. American Health Publishing: Dallas, TX, USA, 1999.

    Google Scholar 

  33. Smith SR, Weissman NJ, Anderson CM, Sanchez M, Chuang E, Stubbe S et al. Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med 2010; 363: 245–256.

    Article  CAS  Google Scholar 

  34. Garvey WT, Ryan DH, Look M, Gadde KM, Allison DB, Peterson CA et al. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine-topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr 2012; 95: 297–308.

    Article  CAS  Google Scholar 

  35. James WP, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 2010; 363: 905–917.

    Article  CAS  Google Scholar 

  36. Mohler PJ . Enhancing compliance with screening mammography recommendations: a clinical trial in a primary care office. Fam Med 1995; 27: 117–121.

    CAS  PubMed  Google Scholar 

  37. Katz DA, Brown RB, Muelenbruch DR, Fiore MC, Baker TB . Implementing guidelines for smoking cessation: comparing the efforts of nurses and medical assistants. Am J Prev Med 2004; 27: 411–416.

    PubMed  Google Scholar 

  38. Tsai AG, Wadden TA, Rogers MA, Day SC, Moore RH, Islam BJ . A primary care intervention for weight loss: results of a randomized controlled pilot study. Obesity 2010; 18: 1614–1618.

    Article  Google Scholar 

  39. Derbas J, Vetter M, Volger S, Khan Z, Panigrahi E, Tsai AG et al. Improving weight management in primary care practice: a possible role for auxiliary health professionals collaborating with primary care physicians. Obesity and Weight Management 2009; 5: 210–215.

    Article  Google Scholar 

  40. National Heart, Lung, and Blood Institute. Aim for a Healthy Weight. National Institutes of Health: Bethesda, MD, USA, 2005. (NIH publication no. 05-5213).

  41. Heymsfield SB, van Mierlo CA, van def Knaap HC, Heo M, Frier HI . Weight management using a meal replacement strategy: meta and pooling analysis from six studies. Int J Obes Relat Metab Disord 2003; 27: 537–549.

    Article  CAS  Google Scholar 

  42. Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM et alWeight Loss Maintenance Collaborative Research Group. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 2008; 299: 1139–1148.

    Article  CAS  Google Scholar 

  43. LeBlanc ES, O’Connor E, Whitlock EP, Patnode CD, Kapka T . Effectiveness of primary care-relevant treatments for obesity in adults: a systematic evidence review for the US Preventive Services Task Force. Ann Intern Med 2011; 155: 434–447.

    Article  Google Scholar 

  44. Tsai AG, Wadden TA . Treatment of obesity in primary care practice in the United States: a systematic review. J Gen Intern Med 2009; 24: 1073–1079.

    Article  Google Scholar 

  45. DiLillo V, West DS . Motivational interviewing for weight loss. In: Wadden TA, Wilson GT, Stunkard AJ, Berkowitz RI, (eds) Psychiatric Clinics of North America- Obesity and Associated Eating Disorders: A Guide for Mental Health Professionals 1st edn. Elsevier Inc.: Philadelphia, PA, USA, 2011. pp 861–870.

    Google Scholar 

  46. Ma J, Yank V, Xiao L, Lavori PW, Wilson SR, Rosas LG et al. Translating the Diabetes Prevention Program lifestyle intervention for weight loss into primary care. JAMA Intern Med 2013; 173: 113–121.

    Article  Google Scholar 

  47. Jebb SA, Ahern AL, Olson AD, Aston LM, Holzapfel C, Stoll J et al. Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet 2011; 378: 1485–1492.

    Article  Google Scholar 

  48. Jolly K, Lewis A, Beach J, Denley J, Adab P, Deeks JJ et al. Comparison of range of commercial or primary care led weight reduction programmes with minimal intervention control for weight loss in obesity: lighten up randomised controlled trial. BMJ 2011; 343: d6500.

    Article  Google Scholar 

  49. Kumanyika SK, Espeland MA, Bahnson JL, Bottom JB, Charleston JB, Folmar S et alTONE Cooperative Research Group. Ethnic comparison of weight loss in the trial of nonpharmacologic interventions in the elderly. Obes Res 2002; 10: 96–106.

    Article  Google Scholar 

  50. Kumanyika SK, Fassbender JE, Sarwer DB, Phipps E, Allison KC, Localio R . One-year results of the Think Health! Study of weight management in primary care practices. Obesity 2012; 20: 1249–1257.

    Article  Google Scholar 

  51. Harvey-Berino J, West D, Krukowski R, Prewitt E, VanBiervliet A, Ashikagha T et al. Internet delivered and behavioral obesity treatment. Prev Med 2010; 51: 123–128.

    Article  Google Scholar 

  52. Krukowski RA, Tilford JM, Harvey-Berino J, West DS . Comparing behavioral weight loss modalities: incremental cost-effectiveness of an internet-based versus an in-person condition. Obesity 2011; 19: 1629–1635.

    Article  Google Scholar 

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Acknowledgements

This research was supported by grants U01-HL087072 from the National Heart, Lung and Blood Institute and K24-DK065018 from the National Institute of Diabetes and Digestive and Kidney Disease. We thank Amos Odeleye for his assistance with statistical analysis.

This article is published as part of a supplement, sponsored by the Center for Weight and Eating Disorders—University of Pennsylvania.

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Correspondence to T A Wadden.

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Competing interests

TAW serves on the advisory boards of Novo Nordisk and Orexigen Therapeutics, which are developing weight loss medications, as well as of Alere and the Cardiometabolic Support Network, which provide behavioral weight loss programs. TAW has also served as a consultant for Boehringer Ingelheim, and has received grant support from the National Institutes of Health (NIH/NIDDK and NIH/NHLBI). AGT has received grant support from the American Hospital Association (AHA), Agency for Healthcare Research and Quality (AHRQ), and American Academy of Family Physicians (AAFP) Foundation. DBS discloses relationships with the following companies: Allergan, BariMD, BaroNova, Enteromedics and Galderma. DBS has also received grant support from the National Institutes of Health (NIH). The remaining authors declare no conflict of interest.

Appendix

Appendix

POWER-UP Research Group: Investigators and Research Coordinators

Academic investigators at the Perelman School of Medicine at the University of Pennsylvania were Thomas A Wadden, PhD (principal investigator), David B Sarwer, PhD (co-principal investigator), Robert I Berkowitz, MD, Jesse Chittams, MS, Lisa Diewald, MS, RD, Shiriki Kumanyika, PhD, Renee Moore, PhD, Kathryn Schmitz, PhD, Adam G Tsai, MD, MSCE, Marion Vetter, MD and Sheri Volger, MS, RD.

Research coordinators at the University of Pennsylvania were Caroline H Moran, BA, Jeffrey Derbas, BS, Megan Dougherty, BS, Zahra Khan, BA, Jeffrey Lavenberg, MA, Eva Panigrahi, MA, Joanna Evans, BA, Ilana Schriftman, BA, Dana Tioxon, Victoria Webb, BA and Catherine Williams-Smith, BS.

POWER-UP Research Group: Participating Sites and Clinical Investigators

PennCare—Bala Cynwyd Medical Associates: Ronald Barg, MD, Nelima Kute, MD, David Lush, MD, Celeste Mruk, MD, Charles Orellana, MD and Gail Rudnitsky, MD (primary care providers); Angela Monroe (lifestyle coach); Lisa Anderson (practice administrator).

PennCare—Internal Medicine Associates of Delaware County: David E Eberly, MD, Albert H Fink Jr, MD, Kathleen Malone, CRNP, Peter B Nonack, MD, Daniel Soffer, MD, John N Thurman, MD and Marc J Wertheimer, MD (primary care providers); Barbara Jean Shovlin, Lanisha Johnson (lifestyle coaches); Jill Esrey (practice administrator).

PennCare—Internal Medicine Mayfair: Jeffrey Heit, MD, Barbara C Joebstl, MD and Oana Vlad, MD (primary care providers); Rose Schneider, Tammi Brandley (lifestyle coaches); Linda Jelinski (practice administrator).

Penn Presbyterian Medical Associates: Joel Griska, MD, Karen J Nichols, MD, Edward G Reis, MD, James W Shepard, MD and Doris Davis-Whitely, PA (primary care providers); Dana Tioxon (lifestyle coach); Charin Sturgis (practice administrator).

PennCare—University City Family Medicine: Katherine Fleming, CRNP, Dana B Greenblatt, MD, Lisa Schaffer, DO, Tamara Welch, MD and Melissa Rosato, MD (primary care providers); Eugonda Butts, Marta Ortiz, Marysa Nieves and Alethea White (lifestyle coach); Cassandra Bullard (practice administrator).

PennCare—West Chester Family Practice: Jennifer DiMedio, CRNP, Melanie Ice, DO, Brandt Loev, DO, John S Potts, DO and Christine Tressel, DO (primary care providers); Iris Perez, Penny Rancy, and Dianne Rittenhouse (lifestyle coaches); Joanne Colligan (practice administrator).

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Wadden, T., Volger, S., Tsai, A. et al. Managing obesity in primary care practice: an overview with perspective from the POWER-UP study. Int J Obes 37 (Suppl 1), S3–S11 (2013). https://doi.org/10.1038/ijo.2013.90

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