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An investigation of antigenic drift of neuraminidases of influenza A (H1N1) viruses

Published online by Cambridge University Press:  19 October 2009

P. Luther ,
K. Ch. Bergmann  and
J. S. Oxford
P. Luther
Affiliation:
Research Institute for Lung Disease, Berlin-Buch, GDR and National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB
K. Ch. Bergmann
Affiliation:
Research Institute for Lung Disease, Berlin-Buch, GDR and National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB
J. S. Oxford
Affiliation:
Research Institute for Lung Disease, Berlin-Buch, GDR and National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB
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Summary

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A newly developed lectin neuraminidase test (LNT) and a panel of mouse monoclonal and post-infection ferret antibodies have been used to analyse antigenic drift in N1 neuraminidases of influenza A viruses isolated between 1933 and 1957 and also between 1977 and 1980. Significant antigenic differences were detected among the ‘early’ (1933–57) viruses since the NA of viruses isolated one year apart could be distinguished serologically. The NA ofthe ‘re-emerged’ virus A/USSR/92/77 (H1N1) was antigenically related but not identical to influenza A viruses isolated in 1949 (A/Paris/49 (H1N1), A/Geneva/49 (H1N1)) which thus predates the previously observed antigenic similarity of A/USSR/77 with A/FW/50 (H1N1) virus.

Type
Research Article
Information
Journal of Hygiene , Volume 92 , Issue 2 , April 1984 , pp. 223 - 229
Copyright
Copyright © Cambridge University Press 1984

References

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